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Specificity of the Antibody Receptor Site to D-Lysergamide: Model of a Physiological Receptor for Lysergic Acid Diethylamide
- Source :
- Proceedings of the National Academy of Sciences. 68:1483-1487
- Publication Year :
- 1971
- Publisher :
- Proceedings of the National Academy of Sciences, 1971.
-
Abstract
- Antibodies to D-lysergic acid have been produced in rabbits and guinea pigs and a radioimmunoassay for the hapten was developed. The specificity of this lysergamide-antilysergamide reaction was determined by competitive binding with unlabeled lysergic acid diethylamide (LSD), psychotomimetic drugs, neurotransmitters, and other compounds with diverse structures. LSD and several related ergot alkaloids were potent competitors, three to seven times more potent than lysergic acid itself. The N , N -dimethyl derivatives of several compounds, including tryptamine, 5-hydroxytryptamine, 4-hydroxytryptamine, 5-methoxytryptamine, tyramine, and mescaline, were only about ten times less effective than lysergic acid, even though these compounds lack some of the ring systems of lysergic acid. The pattern of inhibition by related compounds with various substituents suggests that the antibody receptor site recognizes structural features resembling the LSD molecule. In particular, the aromatic nucleus and the dimethylated ethylamine side chain in phenylethylamine and tryptamine derivatives may assume in solution a conformation resembling ring A and the methylated nitrogen in ring C of LSD. Among the tryptamine derivatives, a large percentage of the most potent competitors are also psychotomimetic compounds.
- Subjects :
- Tryptamine
Ergot Alkaloids
Serotonin
Polymers
Stereochemistry
Receptors, Drug
Guinea Pigs
Radioimmunoassay
Psychotomimetic drug
Tyramine
Mescaline
Cross Reactions
Antigen-Antibody Reactions
chemistry.chemical_compound
Iodine Isotopes
Antibody receptor
Phenethylamines
Ergotamine
medicine
Animals
Amines
Ergolines
Sympathomimetics
Ergonovine
Melatonin
Lysergic acid diethylamide
Binding Sites
Multidisciplinary
Chemistry
Immune Sera
Lysine
Psychotomimetic
Tryptamines
Psilocybin
Lysergic acid
Lysergic Acid Diethylamide
Biochemistry
Hemocyanins
Sympatholytics
Biological Sciences: Biochemistry
Rabbits
Haptens
Hapten
medicine.drug
Subjects
Details
- ISSN :
- 10916490 and 00278424
- Volume :
- 68
- Database :
- OpenAIRE
- Journal :
- Proceedings of the National Academy of Sciences
- Accession number :
- edsair.doi.dedup.....463f2791f3efb5d495f99f4341c040be