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Low fish oil intake improves insulin sensitivity, lipid profile and muscle metabolism on insulin resistant MSG-obese rats
- Source :
- Lipids in Health and Disease, Lipids in Health and Disease, Vol 10, Iss 1, p 66 (2011)
- Publisher :
- Springer Nature
-
Abstract
- Background Obesity is commonly associated with diabetes, cardiovascular diseases and cancer. The purpose of this study was to determinate the effect of a lower dose of fish oil supplementation on insulin sensitivity, lipid profile, and muscle metabolism in obese rats. Methods Monosodium glutamate (MSG) (4 mg/g body weight) was injected in neonatal Wistar male rats. Three-month-old rats were divided in normal-weight control group (C), coconut fat-treated normal weight group (CO), fish oil-treated normal weight group (FO), obese control group (Ob), coconut fat-treated obese group (ObCO) and fish oil-treated obese group (ObFO). Obese insulin-resistant rats were supplemented with fish oil or coconut fat (1 g/kg/day) for 4 weeks. Insulin sensitivity, fasting blood biochemicals parameters, and skeletal muscle glucose metabolism were analyzed. Results Obese animals (Ob) presented higher Index Lee and 2.5 fold epididymal and retroperitoneal adipose tissue than C. Insulin sensitivity test (Kitt) showed that fish oil supplementation was able to maintain insulin sensitivity of obese rats (ObFO) similar to C. There were no changes in glucose and HDL-cholesterol levels amongst groups. Yet, ObFO revealed lower levels of total cholesterol (TC; 30%) and triacylglycerol (TG; 33%) compared to Ob. Finally, since exposed to insulin, ObFO skeletal muscle revealed an increase of 10% in lactate production, 38% in glycogen synthesis and 39% in oxidation of glucose compared to Ob. Conclusions Low dose of fish oil supplementation (1 g/kg/day) was able to reduce TC and TG levels, in addition to improved systemic and muscle insulin sensitivity. These results lend credence to the benefits of n-3 fatty acids upon the deleterious effects of insulin resistance mechanisms.
- Subjects :
- Male
medicine.medical_specialty
medicine.medical_treatment
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Adipose tissue
Carbohydrate metabolism
Biology
Fish Oils
Insulin resistance
Endocrinology
Diabetes mellitus
Internal medicine
Sodium Glutamate
medicine
Animals
Insulin
Obesity
Rats, Wistar
Muscle, Skeletal
lcsh:RC620-627
Biochemistry, medical
medicine.diagnostic_test
Research
Fatty Acids
Biochemistry (medical)
Skeletal muscle
Feeding Behavior
medicine.disease
Fish oil
Lipids
Diet
Rats
lcsh:Nutritional diseases. Deficiency diseases
medicine.anatomical_structure
Insulin Resistance
Lipid profile
Subjects
Details
- Language :
- English
- ISSN :
- 1476511X
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Lipids in Health and Disease
- Accession number :
- edsair.doi.dedup.....4633b0038412be8b5e041a277f19c118
- Full Text :
- https://doi.org/10.1186/1476-511x-10-66