Back to Search
Start Over
The multi-cancer marker, rs6983267, located at region 3 of chromosome 8q24, is associated with prostate cancer in Greek patients but does not contribute to the aggressiveness of the disease
- Source :
- Clinical chemistry and laboratory medicine. 50(2)
- Publication Year :
- 2011
-
Abstract
- Recently, several polymorphisms located on human chromosome 8q24 were found to be associated with prostate cancer risk with different frequency and incidence among the investigated populations. The authors conducted a prostate cancer case-control study in the Greek population to evaluate the association of the single nucleotide polymorphism (SNP) rs6983267, located at region 3 of chromosome 8q24, with this type of cancer.Samples of total blood from 86 patients with histologically confirmed prostate cancer and 99 healthy individuals were genotyped using real time polymerase chain reaction (PCR). Tumor-node-metastasis (TNM) stage, Gleason score and levels of prostate-specific antigen (PSA) at diagnosis were included in the analysis.A highly significant association (odds ratio=2.84 and p-value=0.002) was found between rs6983267 and prostate cancer in the Greek population. The sensitivity, specificity, negative and positive predictive values of the presence of G allele for the discrimination between patients and controls were 81.40%, 39.4%, 53.9% and 70.9%, respectively. A lower proportion of homozygotes was found in patients with PSA level The SNP rs6983267 is an established marker for a range of cancers. In prostate cancer, it indicates an enhanced risk for carriers to develop the disease in general. In our study it showed no association with aggressive forms or familial and early-onset prostate cancer families.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Genotype
Clinical Biochemistry
Single-nucleotide polymorphism
Polymorphism, Single Nucleotide
Prostate cancer
Polymorphism (computer science)
Internal medicine
Neoplasms
medicine
Biomarkers, Tumor
SNP
Humans
Genetic Predisposition to Disease
Aged
Greece
business.industry
Incidence (epidemiology)
Biochemistry (medical)
Cancer
Prostatic Neoplasms
General Medicine
Odds ratio
medicine.disease
business
Chromosomes, Human, Pair 8
Subjects
Details
- ISSN :
- 14374331
- Volume :
- 50
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical chemistry and laboratory medicine
- Accession number :
- edsair.doi.dedup.....462a62f70c3fbfdb917c7893498f3bab