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Expression of the transcripts initiated in the 62nd intron of the dystrophin gene
- Source :
- Neuromuscular Disorders. 3:519-524
- Publication Year :
- 1993
- Publisher :
- Elsevier BV, 1993.
-
Abstract
- The pattern of expression of two distal transcripts initiated in the 62nd intron of the dystrophin gene was investigated under different circumstances: (i) during the development of different rat tissues these transcripts and Dp 71, a protein encoded by one of them, increased with brain development and decreased with muscle development; (ii) in cultured glial and neuronal cells, the distal promoter was coactivated with tissue-specific upstream promoters, the muscle-type promoter in glial cells and the brain-type promoter in neuronal cells, which suggests that activity of the upstream promoter does not interfere with activity of the distal promoter; (iii) in lymphoblasts of DMD patients with various deletions of the dystrophin gene, the most distal of which included the 56th intron, the production of the distal transcript was not perturbed.
- Subjects :
- Brain development
Transcription, Genetic
Molecular Sequence Data
Gene Expression
Biology
Polymerase Chain Reaction
Muscular Dystrophies
Dystrophin
Animals
Humans
Lymphocytes
Child
Promoter Regions, Genetic
Genetics (clinical)
DNA Primers
Base Sequence
Lymphoblast
Intron
A protein
Promoter
Molecular biology
Dystrophin gene
Introns
Rats
Real-time polymerase chain reaction
Liver
Neurology
Pediatrics, Perinatology and Child Health
Neurology (clinical)
Gene Deletion
Subjects
Details
- ISSN :
- 09608966
- Volume :
- 3
- Database :
- OpenAIRE
- Journal :
- Neuromuscular Disorders
- Accession number :
- edsair.doi.dedup.....4613af37ce50cb0d6fcfd24fc010ae09