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Predictive value of heart rate deceleration capacity on coronary artery lesion in acute phase of Kawasaki disease
- Source :
- Scientific Reports, Scientific Reports, Vol 10, Iss 1, Pp 1-6 (2020)
- Publication Year :
- 2020
- Publisher :
- Nature Publishing Group UK, 2020.
-
Abstract
- This study was to investigate the correlation of vagal activity with coronary artery lesion (CAL) in Kawasaki disease (KD) children, and assess the predictive value of heart rate deceleration capacity (DC) for CAL in acute phase of KD.50 KD children with CAL, 130 KD children without CAL, 30 children with acute upper respiratory infection and 100 healthy children were recruited and indicators reflecting vagal activity including DC were measstuogram. KD children with CAL showed decreased vagal activity with significantly lower values of DC. DC was negatively correlated with levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) and C-reactive protein (CRP) in KD children. DC was a usable cardiac electrophysiological index to predict CAL in children with KD, with an area under the receiver operating characteristic curve (AUC) of 0.741. The cut-off value of DC for predicting CAL in KD children was 4.37 ms. DC was an independent predictor of CAL in children with KD, evaluated by multiple logistic regression analysis, KD children with DC ≤ 4.37 ms had an increased risk of CAL, with odds ratios (OR) of 5.94. Our study illustrates DC could be used to predict CAL in acute phase of KD.
- Subjects :
- Vasculitis
Male
medicine.medical_specialty
medicine.drug_class
Deceleration
lcsh:Medicine
Coronary Artery Disease
030204 cardiovascular system & hematology
Mucocutaneous Lymph Node Syndrome
Article
03 medical and health sciences
0302 clinical medicine
Heart Rate
030225 pediatrics
Internal medicine
Heart rate
medicine
Natriuretic peptide
Humans
lcsh:Science
Multidisciplinary
Receiver operating characteristic
business.industry
lcsh:R
Case-control study
Coronary artery lesion
Infant
Odds ratio
medicine.disease
Prognosis
Predictive value
humanities
stomatognathic diseases
Risk factors
ROC Curve
Case-Control Studies
Child, Preschool
biological sciences
Acute Disease
Cardiology
Kawasaki disease
lcsh:Q
Female
business
Biomarkers
Follow-Up Studies
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....4605e08e7fa00d525ee93246deda57e3