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Using Healthcare Databases to Refine Understanding of Exploratory Associations Between Drugs and Progression of Open-Angle Glaucoma
- Source :
- Clinical pharmacology and therapeutics. 106(4)
- Publication Year :
- 2019
-
Abstract
- We sought to refine understanding about associations identified in prior studies between angiotensin-II receptor blockers, metformin, selective serotonin reuptake inhibitors, fibric-acid derivatives, or calcium channel blockers and progression to glaucoma filtration surgery for open-angle glaucoma (OAG). We used new-initiator, active-comparator cohort designs to investigate these drugs in two data sources. We adjusted for confounders using stabilized inverse-probability-of-treatment weights and evaluated results using "intention-to-treat" and "as-treated" follow-up approaches. In both data sources, Kaplan-Meier curves showed trends for more rapid progression to glaucoma filtration surgery in patients taking calcium channel blockers compared with thiazides with as-treated (MarketScan P = 0.15; Medicare P = 0.03) and intention-to-treat follow-up (MarketScan P < 0.01; Medicare P = 0.10). There was suggestion of delayed progression for selective serotonin reuptake inhibitor compared with tricyclic antidepressants in Medicare, which was not observed in MarketScan. Our study provided support for a relationship between calcium channel blockers and OAG progression but not for other investigated drugs.
- Subjects :
- Oncology
Male
medicine.medical_specialty
Open angle glaucoma
Drug-Related Side Effects and Adverse Reactions
Serotonin reuptake inhibitor
Glaucoma
Kaplan-Meier Estimate
Medicare
030226 pharmacology & pharmacy
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Internal medicine
medicine
Humans
Hypoglycemic Agents
Pharmacology (medical)
Antihypertensive Agents
Aged
Pharmacology
chemistry.chemical_classification
business.industry
Calcium channel
Confounding
Confounding Factors, Epidemiologic
medicine.disease
Calcium Channel Blockers
Antidepressive Agents
United States
Metformin
chemistry
030220 oncology & carcinogenesis
Cohort
Disease Progression
Female
business
Glaucoma, Open-Angle
Tricyclic
medicine.drug
Subjects
Details
- ISSN :
- 15326535
- Volume :
- 106
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Clinical pharmacology and therapeutics
- Accession number :
- edsair.doi.dedup.....45ffc335763aa4ab22be15347701c07a