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Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Münster protocols
- Source :
- Blood. 114:1314-1318
- Publication Year :
- 2009
- Publisher :
- American Society of Hematology, 2009.
-
Abstract
- Thiopurine methyltransferase (TPMT)is involved in the metabolism of thiopurines such as 6-mercaptopurine and 6-thioguanine. TPMT activity is significantly altered by genetics, and heterozygous and even more homozygous variant people reveal substiantially decreased TPMT activity. Treatment for childhood acute lymphoblastic leukemia (ALL) regularly includes the use of thiopurine drugs. Importantly, childhood ALL patients with low TPMT activity have been considered to be at increased risk of developing therapy-associated acute myeloid leukemia and brain tumors. In the present study, we genotyped 105 of 129 patients who developed a secondary malignant neoplasm after ALL treatment on 7 consecutive German Berlin-Frankfurt-Münster trials for all functionally relevant TPMT variants. Frequencies of TPMT variants were similarly distributed in secondary malignant neoplasm patients and the overall ALL patient population of 814 patients. Thus, TPMT does not play a major role in the etiology of secondary malignant neoplasm after treatment for childhood ALL, according to Berlin-Frankfurt-Münster strategies.
- Subjects :
- Male
Heterozygote
medicine.medical_specialty
Vincristine
Immunology
Biochemistry
Thiopurine S-Methyltransferase
Risk Factors
Germany
Internal medicine
Acute lymphocytic leukemia
Antineoplastic Combined Chemotherapy Protocols
medicine
Asparaginase
Humans
Child
Childhood Acute Lymphoblastic Leukemia
Genetics
Hematology
Thiopurine methyltransferase
biology
Brain Neoplasms
business.industry
Daunorubicin
Homozygote
Infant
Cancer
Myeloid leukemia
Neoplasms, Second Primary
Methyltransferases
Cell Biology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
medicine.disease
Leukemia, Myeloid, Acute
Child, Preschool
biology.protein
Prednisone
Female
business
Follow-Up Studies
medicine.drug
Subjects
Details
- ISSN :
- 15280020 and 00064971
- Volume :
- 114
- Database :
- OpenAIRE
- Journal :
- Blood
- Accession number :
- edsair.doi.dedup.....45fa8227801ce7edaa3294860ca1b02a