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Lupus Erythematosus Panniculitis: Clinicopathological, Immunophenotypic, and Molecular Studies
- Source :
- The American Journal of Dermatopathology. 32:24-30
- Publication Year :
- 2010
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2010.
-
Abstract
- Lupus erythematosus panniculitis (LEP) is an inflammatory disorder of the subcutaneous fat in patients with lupus erythematosus (LE). It is a rare variant of the disease, which occurs approximately in 1%-3% of patients with cutaneous LE. The purpose of this study was to investigate the clinical, histopathologic, immunophenotypical, and molecular profiles of LEP. We performed a retrospective study of 19 biopsy specimens from 17 patients with LEP. We reviewed their clinical data and reexamined the histopathology. Immunophenotyping and molecular studies were done using sections from paraffin-embedded formalin-fixed tissue. The most common clinical manifestation was a depressed patch on upper arm. Patients showed good response to variable treatment modalities, but, generally, relapse of panniculitis was noted when treatment was discontinued. Histopathologically, most specimens revealed lymphoplasmacytic lobular panniculitis with epidermal and dermal changes of LE, hyaline fat necrosis, and lymphoid follicles. Immunohistochemistry showed a mixture of T and B cells in dermis and subcutis with a slight preponderance of T cell. Although the polymerase chain reaction analysis of the T-cell receptor-gamma gene rearrangement showed a polyclonal smear in 89.5% of cases, a small portion of specimens demonstrated monoclonality. LEP is a chronic recurrent disease with characteristic features. Its diagnosis is often challenging, and a precise diagnosis is achievable only upon elaborate clinicopathologic correlation and integrated interpretation of all diagnostic criteria.
- Subjects :
- Adult
Male
Pathology
medicine.medical_specialty
Adolescent
Prednisolone
T-Lymphocytes
Dermatology
Immunophenotyping
Pathology and Forensic Medicine
Immunoenzyme Techniques
Young Adult
Panniculitis, Lupus Erythematosus
Biopsy
Humans
Medicine
Fat necrosis
Fat Necrosis
Child
Aged
Retrospective Studies
Skin
B-Lymphocytes
Lupus erythematosus
medicine.diagnostic_test
Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor
business.industry
General Medicine
Gene rearrangement
Middle Aged
medicine.disease
Methotrexate
Drug Therapy, Combination
Female
Histopathology
business
Panniculitis
Dapsone
Biomarkers
Lupus erythematosus panniculitis
Hydroxychloroquine
Subjects
Details
- ISSN :
- 01931091
- Volume :
- 32
- Database :
- OpenAIRE
- Journal :
- The American Journal of Dermatopathology
- Accession number :
- edsair.doi.dedup.....45f12faee39f6c4afa7ebdd8b02b47ae