Back to Search
Start Over
Development and validation of a nomogram for predicting acute kidney injury after orthotopic liver transplantation
- Source :
- Renal Failure, Vol 43, Iss 1, Pp 1588-1600 (2021), Renal Failure, article-version (VoR) Version of Record
- Publication Year :
- 2021
- Publisher :
- Taylor & Francis Group, 2021.
-
Abstract
- Background We aim to develop and validate a nomogram model for predicting severe acute kidney injury (AKI) after orthotopic liver transplantation (OLT). Methods A total of 576 patients who received OLT in our center were enrolled. They were assigned to the development and validation cohort according to the time of inclusion. Univariable and multivariable logistic regression using the forward variable selection routine were applied to find risk factors for post-OLT severe AKI. Based on the results of multivariable analysis, a nomogram was developed and validated. Patients were followed up to assess the long-term mortality and development of chronic kidney disease (CKD). Results Overall, 35.9% of patients were diagnosed with severe AKI. Multivariable logistic regression analysis revealed that recipients’ BMI (OR 1.10, 95% CI 1.04–1.17, p = 0.012), hypertension (OR 2.32, 95% CI 1.22–4.45, p = 0.010), preoperative serum creatine (sCr) (OR 0.96, 95% CI 0.95–0.97, p 0.05). Kaplan-Meier survival analysis showed that patients in the high-risk group stratified by the nomogram suffered significantly poorer long-term survival than the low-risk group (HR 1.92, p
- Subjects :
- Male
prediction nomogram
Critical Care and Intensive Care Medicine
urologic and male genital diseases
Severity of Illness Index
survival
Postoperative Complications
Predictive Value of Tests
Risk Factors
Humans
liver transplantation
severe
General Medicine
Middle Aged
Survival Analysis
Diseases of the genitourinary system. Urology
Nomograms
acute kidney injury
Nephrology
ckd
Clinical Study
Female
prognosis
RC870-923
Biomarkers
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15256049
- Volume :
- 43
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Renal Failure
- Accession number :
- edsair.doi.dedup.....45e63bbac6e236395cb91a5e715e30c0