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Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
- Source :
- Karavasiloglou, N, Hughes, D J, Murphy, N, Schomburg, L, Sun, Q, Seher, V, Rohrmann, S, Weiderpass, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M-C, Mancini, F R, Mahamat-Saleh, Y, Kaaks, R, Kuhn, T, Schulze, M B, Tumino, R, Panico, S, Masala, G, Pala, V, Sacerdote, C, Derksen, J W G, Skeie, G, Hjartåker, A, Lasheras, C, Agudo, A, Sánchez, M-J, Chirlaque, M-D, Ardanaz, E, Amiano, P, Van Guelpen, B, Gylling, B, Bradbury, K E, Papier, K, Freisling, H, Aglago, E K, Cross, A J, Riboli, E, Aune, D, Gunter, M J & Jenab, M 2023, ' Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts ', The American Journal of Clinical Nutrition, vol. 117, no. 1, pp. 33-45 . https://doi.org/10.1016/j.ajcnut.2022.10.004
- Publication Year :
- 2022
- Publisher :
- Oxford University Press, 2022.
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Abstract
- BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk.OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies.METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts.RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: OR Q5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: OR Q5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: OR Q5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: OR Q5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum. CONCLUSIONS: In UK-BB, higher serum ionized calcium levels were inversely associated with CRC, but the risk was restricted to the colon. Total serum calcium showed a null association in EPIC. Additional prospective studies in other populations are needed to better investigate these associations.
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Karavasiloglou, N, Hughes, D J, Murphy, N, Schomburg, L, Sun, Q, Seher, V, Rohrmann, S, Weiderpass, E, Tjønneland, A, Olsen, A, Overvad, K, Boutron-Ruault, M-C, Mancini, F R, Mahamat-Saleh, Y, Kaaks, R, Kuhn, T, Schulze, M B, Tumino, R, Panico, S, Masala, G, Pala, V, Sacerdote, C, Derksen, J W G, Skeie, G, Hjartåker, A, Lasheras, C, Agudo, A, Sánchez, M-J, Chirlaque, M-D, Ardanaz, E, Amiano, P, Van Guelpen, B, Gylling, B, Bradbury, K E, Papier, K, Freisling, H, Aglago, E K, Cross, A J, Riboli, E, Aune, D, Gunter, M J & Jenab, M 2023, ' Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts ', The American Journal of Clinical Nutrition, vol. 117, no. 1, pp. 33-45 . https://doi.org/10.1016/j.ajcnut.2022.10.004
- Accession number :
- edsair.doi.dedup.....45e1329e444899782ce4038e2df97a40