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The Value of Early and Follow-Up Elevated Scores Based on Peripheral Complete Blood Cell Count for Predicting Adverse Outcomes in COVID-19 Patients

Authors :
Andrei-Costin Chelariu
Adorata Elena Coman
Catalina Lionte
Victoria Gorciac
Victorita Sorodoc
Raluca Ecaterina Haliga
Ovidiu Rusalim Petris
Cristina Bologa
Gabriela Puha
Alexandra Stoica
Mihai Constantin
Oana Sirbu
Alexandr Ceasovschih
Laurentiu Sorodoc
Source :
Journal of Personalized Medicine; Volume 12; Issue 12; Pages: 2037
Publication Year :
2022
Publisher :
Multidisciplinary Digital Publishing Institute, 2022.

Abstract

Background: The ongoing COVID-19 pandemic has put a constant strain on hospital resources, so there is a dire need for investigation methods that are widely available and that can predict mortality and the need for critical care. Hematological indices, which can be easily calculated from a complete blood count (CBC), are useful in determining a patient’s inflammatory response to infectious diseases. Aim: This was a prospective cohort study that aimed to assess the prognostic value of scores based on CBCs in hospitalized patients with mild or moderate COVID-19 and medical comorbidities regarding the need for intensive care unit (ICU) therapy and short-term mortality. Methods: We included 607 patients with confirmed COVID-19, followed up for the need for ICU admission (15.5%) and 30 day mortality post-discharge (21.7%). CBC-derived scores were tested upon emergency department (ED) admission and after a median of 8 days. Results: In a multivariate model, elevated followed-up neutrophil-to-lymphocyte ratio (NLR) predicted increased odds for ICU admission (OR: 1.14 [95%CI: 1.06–1.22], p < 0.001) and short-term mortality (OR: 1.30 [95%CI: 1.09–1.57], p = 0.005). Monocyte-to-lymphocyte ratio (MLR) predicted 2.5-fold increased odds for ICU admission and 2.2-fold increased odds for mortality. Conclusion: NLR and MLR followed up 8 days post-admission are predictive for adverse outcomes in mild or moderate COVID-19 patients.

Details

Language :
English
ISSN :
20754426
Database :
OpenAIRE
Journal :
Journal of Personalized Medicine; Volume 12; Issue 12; Pages: 2037
Accession number :
edsair.doi.dedup.....45dde77c6649c6b4e0e4f03d5e51190c
Full Text :
https://doi.org/10.3390/jpm12122037