Back to Search
Start Over
Comparison of livestock-associated and community-associated Staphylococcus aureus pathogenicity in a mouse model of skin and soft tissue infection
- Source :
- Scientific Reports, Scientific Reports, Vol 9, Iss 1, Pp 1-10 (2019)
- Publication Year :
- 2019
- Publisher :
- Nature Publishing Group UK, 2019.
-
Abstract
- Industrial hog operation (IHO) workers are at increased risk of carrying Staphylococcus aureus in their nares, particularly strains that are livestock-associated (LA) and multidrug-resistant. The pathogenicity of LA-S. aureus strains remains unclear, with some prior studies suggesting reduced transmission and virulence in humans compared to community-associated methicillin-resistant (CA-MRSA) S. aureus. The objective of this study was to determine the degree to which LA-S. aureus strains contracted by IHO workers cause disease relative to a representative CA-MRSA strain in a mouse model of skin and soft tissue infection (SSTI). Mice infected with CC398 LA-S. aureus strains (IHW398-1 and IHW398-2) developed larger lesion sizes with higher bacterial burden than mice infected with CA-MRSA (SF8300) (p S. aureus infected mice had decreased IL-1β protein levels compared with CA-MRSA-infected mice (p S. aureus SSTIs. WGSA revealed heterogeneity in virulence factor and antimicrobial resistance genes carried by LA-S. aureus and CA-MRSA strains. The observed pathogenicity suggest that more attention should be placed on preventing the spread of LA-S. aureus into human populations.
- Subjects :
- Methicillin-Resistant Staphylococcus aureus
0301 basic medicine
Livestock
lcsh:Medicine
Virulence
Biology
medicine.disease_cause
Virulence factor
Article
Microbiology
Lesion
Mice
03 medical and health sciences
0302 clinical medicine
medicine
Animals
Skin Diseases, Infectious
lcsh:Science
Author Correction
Poultry Diseases
Multidisciplinary
Strain (chemistry)
Transmission (medicine)
Soft Tissue Infections
lcsh:R
Staphylococcal Infections
Pathogenicity
Community-Acquired Infections
Disease Models, Animal
030104 developmental biology
Staphylococcus aureus
lcsh:Q
Soft tissue infection
medicine.symptom
Bacterial infection
Infection
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....45dd5b319e92dc54d5eefdd869b4e49a