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Decreased Resting-State Activity in the Precuneus Is Associated With Depressive Episodes in Recurrent Depression
- Source :
- Journal of Clinical Psychiatry
- Publication Year :
- 2017
- Publisher :
- Physicians Postgraduate Press, Inc, 2017.
-
Abstract
- OBJECTIVE: To investigate alterations in resting-state spontaneous brain activity in patients with major depressive disorder MDD) experiencing multiple episodes. METHODS: Between May 2007 and September 2014, 24 recurrent and 22 remitted patients diagnosed with MDD with the Structured Clinical Interview for DSM-IV Axis I Disorders (SCID-I), and 69 healthy controls matched for age, sex, and educational level participated in this study. Among them, 1 healthy control was excluded due to excessive head motion. The fractional amplitude of low-frequency fluctuation (fALFF) was assessed for all recruited subjects during the completion of resting-state functional magnetic resonance imaging. Relationships between fALFF and clinical measurements, including number of depressive episodes and illness duration, were examined. RESULTS: Compared to patients with remitted MDD and to healthy controls, patients with recurrent MDD exhibited decreased fALFF in the right posterior insula and right precuneus and increased fALFF in the left ventral anterior cingulate cortex. Decreased fALFF in the right precuneus and increased fALFF in the right middle insula were correlated with the number of depressive episodes in the recurrent MDD groups (r = -0.75, P < .01 and r = 0.78, P < .01, respectively) and remitted MDD groups (r = -0.63, P < .01 and r = 0.41, P = .03, respectively). In addition to regions in the default mode network (DMN) and salience network, the altered resting-state activity in the middle temporal and visual cortices was also identified. CONCLUSIONS: Altered resting-state activity was observed across several neural networks in patients with recurrent MDD. Consistent with the emerging theory that altered DMN activity is a risk factor for depression relapses, the association between reduced fALFF in the right precuneus and number of depressive episodes supports the role of the DMN in the pathology of recurrent depression.
- Subjects :
- Adult
Male
medicine.medical_specialty
Precuneus
behavioral disciplines and activities
03 medical and health sciences
0302 clinical medicine
Recurrence
Parietal Lobe
Internal medicine
mental disorders
medicine
Humans
Psychiatry
Anterior cingulate cortex
Default mode network
Depression (differential diagnoses)
Depressive Disorder, Major
Resting state fMRI
medicine.diagnostic_test
Functional Neuroimaging
Remission Induction
Middle Aged
medicine.disease
Magnetic Resonance Imaging
030227 psychiatry
Psychiatry and Mental health
medicine.anatomical_structure
Cardiology
Major depressive disorder
Female
Psychology
Functional magnetic resonance imaging
Insula
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 01606689
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- The Journal of Clinical Psychiatry
- Accession number :
- edsair.doi.dedup.....45db5aa9facec54673ca0019ac0880ba