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Predictive value of PD-L1 and other clinical factors for chemoimmunotherapy in advanced non-small-cell lung cancer
- Source :
- Future Oncology. 15:2371-2383
- Publication Year :
- 2019
- Publisher :
- Future Medicine Ltd, 2019.
-
Abstract
- We investigate if PD-L1 expression and other clinical characteristics predict chemoimmunotherapy (CIT) benefits versus chemotherapy in advanced non-small-cell lung cancer. We performed a meta-analysis of randomized controlled trials of CIT versus chemotherapy identified through electronic searches. In seven randomized controlled trials (n = 4170), CIT prolonged progression-free survival over chemotherapy (hazard ratio [HR]: 0.62; 95% CI: 0.58–0.67; p < 0.00001). The treatment benefits differed between PD-L1-high (HR: 0.41; 95% CI: 0.34–0.49) and PD-L1 low (HR: 0.63; 95% CI: 0.55–0.72; interaction-p = 0.00002) and PD-L1-high and PD-L1-negative (HR: 0.72; 95% CI: 0.65–0.80; interaction-p < 0.00001). Similar benefits were observed regardless of gender, EGFR/ALK status and histological subtype. PD-L1 status is predictive of CIT benefit and may assist patient selection and design of future trials.
- Subjects :
- 0301 basic medicine
Oncology
Cancer Research
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
B7-H1 Antigen
law.invention
03 medical and health sciences
Antineoplastic Agents, Immunological
Sex Factors
0302 clinical medicine
Randomized controlled trial
law
Chemoimmunotherapy
Carcinoma, Non-Small-Cell Lung
Internal medicine
PD-L1
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Progression-free survival
Lung cancer
Neoplasm Staging
Randomized Controlled Trials as Topic
Chemotherapy
biology
business.industry
Patient Selection
Hazard ratio
General Medicine
medicine.disease
Progression-Free Survival
030104 developmental biology
030220 oncology & carcinogenesis
Meta-analysis
biology.protein
business
Subjects
Details
- ISSN :
- 17448301 and 14796694
- Volume :
- 15
- Database :
- OpenAIRE
- Journal :
- Future Oncology
- Accession number :
- edsair.doi.dedup.....45cfa25c71263ed625a58a73e9ec2136