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Similarities between ATP-dependent and ion-coupled multidrug transporters
- Source :
- Biochemical Society Transactions. 33:1008-1011
- Publication Year :
- 2005
- Publisher :
- Portland Press Ltd., 2005.
-
Abstract
- The movement of drugs across biological membranes is mediated by two major classes of membrane transporters. Primary-active, ABC (ATP-binding cassette) multidrug transporters are dependent on ATP-binding/hydrolysis, whereas secondary-active multidrug transporters are coupled to the proton (or sodium)-motive force that exists across the plasma membrane. Recent work on LmrA, an ABC multidrug transporter in Lactococcus lactis, suggests that primary- and secondary-active multidrug transporters share functional and structural features. Some of these similarities and their implications for the mechanism of transport by ABC multidrug transporters will be discussed.
- Subjects :
- biology
Chemistry
Lactococcus lactis
Membrane Transport Proteins
Membrane Transporters
Biological membrane
biology.organism_classification
Biochemistry
Antiporters
Drug Resistance, Multiple
Adenosine Triphosphate
Membrane
Multidrug Resistance-Associated Proteins
Multidrug transporter
ATP-binding domain of ABC transporters
Subjects
Details
- ISSN :
- 14708752 and 03005127
- Volume :
- 33
- Database :
- OpenAIRE
- Journal :
- Biochemical Society Transactions
- Accession number :
- edsair.doi.dedup.....45c5aff9502892ff2e380c587031012a