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Association between Cellular Human Immunodeficiency Virus DNA Level and Immunological Parameters in Patients with Undetectable Plasma Viremia Level during Highly Active Antiretroviral Therapy
- Publication Year :
- 2005
- Publisher :
- American Society for Microbiology, 2005.
-
Abstract
- The association between human immunodeficiency virus (HIV) DNA load and immunologic parameters was investigated in 163 HIV-infected patients with undetectable plasma viremia during highly active antiretroviral therapy (HAART). Patients with HIV DNA below the 25th percentile (133 copies/10 6 peripheral blood mononuclear cells) had higher pre-HAART ( P = 0.001) and current ( P = 0.005) CD4 counts and a prolonged duration of treatment ( P = 0.001). At adjusted analysis, prolonged duration of treatment was independently associated with lower ( P = 0.006) and undetectable ( P < 0.001) HIV DNA values.
- Subjects :
- Male
peripheral blood mononuclear cell
RNA directed DNA polymerase inhibitor
HIV Infections
chemistry.chemical_compound
Antiretroviral Therapy, Highly Active
Viral
clinical article
antiretrovirus agent
Human immunodeficiency virus
drug effect
article
virus diseases
highly active antiretroviral therapy
Middle Aged
Viral Load
priority journal
Lentivirus
Human Immunodeficiency Virus DNA
Female
Viral disease
Viral load
Microbiology (medical)
virus DNA
Adult
Settore MED/17 - Malattie Infettive
Antiretroviral Therapy
Viremia
Biology
Peripheral blood mononuclear cell
Virus
Human immunodeficiency virus infection
Virology
medicine
proteinase inhibitor
Humans
Highly Active
human
Aged
long term care
nonhuman
treatment duration
CD4 lymphocyte count
DNA
virus load
biology.organism_classification
medicine.disease
drug efficacy
chemistry
Immunology
DNA, Viral
treatment outcome
HIV-1
adult
female
male
viremia
DNA viruses
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....45bf76f1e23594d4b7fc969fda97c9ae