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Use of thiazolidinediones does not affect prostate-specific antigen levels in men with diabetes
- Source :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology. 18(6)
- Publication Year :
- 2009
-
Abstract
- Thiazolidinediones (TZD) have been shown to down-regulate prostate-specific antigen (PSA) levels in prostate cancer cell lines and decrease PSA velocity among prostate cancer patients; however, the effect of TZDs on serum PSA levels among men with diabetes at risk for prostate cancer is unknown. We conducted a retrospective cohort study of veterans receiving care for diabetes between 1999 and 2005 to determine if TZD use affects PSA levels in veterans at risk for prostate cancer. Eligible patients were male, ≥45 years old, taking at least one oral antidiabetic medication, and with two or more recorded PSA values. Patients with a prior history of prostate cancer or prostatectomy were excluded. Of the 13,791 patients included in the adjusted analysis, 2,016 (14.6%) were prescribed a TZD. No effect of cumulative TZD dose on change in PSA was detected (P = 0.26). Increased TZD exposure was not associated with a change in PSA, suggesting that TZD treatment for diabetes is unlikely to affect prostate cancer detection. (Cancer Epidemiol Biomarkers Prev 2009;18(6):1937–8)
- Subjects :
- Oncology
Male
medicine.medical_specialty
endocrine system diseases
Epidemiology
medicine.medical_treatment
urologic and male genital diseases
Article
Cohort Studies
Prostate cancer
Prostate
Internal medicine
Diabetes mellitus
medicine
Diabetes Mellitus
Humans
Hypoglycemic Agents
Retrospective Studies
Gynecology
PSA Velocity
Prostatectomy
business.industry
Cancer
Prostatic Neoplasms
Retrospective cohort study
Middle Aged
Prostate-Specific Antigen
medicine.disease
Prostate-specific antigen
medicine.anatomical_structure
Thiazolidinediones
business
Subjects
Details
- ISSN :
- 15387755
- Volume :
- 18
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Cancer epidemiology, biomarkersprevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
- Accession number :
- edsair.doi.dedup.....45b0b4515350f3ffa8dc4aed01893318