Supplementary Figures 1 through 7 from H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences

Supplementary Figure S1. Generation of conditional knock-in mice that express the H-RasG12V oncoprotein from the K-Ras locus. Supplementary Figure S2. Flow cytometry analysis of myeloid cell expansion in spleens and BM of H-RasG12V expressing mice. Supplementary Figure S3. Characterization of the T-ALL induced by the H-RasG12V oncoprotein expressed from the K-Ras locus. Supplementary Figure S4. Pancreatic and lung lesions in mice expressing H-RasG12V and K-RasG12V oncoproteins from the K-Ras locus. Supplementary Figure S5. Lack of apoptosis or canonical OIS in lung cells expressing the H-RasG12V oncoprotein from the K-Ras locus. Supplementary Figure S6. H-RasG12V induced senescence-like arrest in lung cells is partially mediated by p53. Supplementary Figure S7. Differential effects of expressing the K-RasG12V and H-RasG12V oncoproteins driven from the K-Ras locus in MEFs.