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Characterizing the cognitive effects of cocaine. A comprehensive review
- Source :
- Neuroscience and Biobehavioral Reviews, 37(8), 1838-1859. Elsevier Science, Neuroscience and Biobehavioral Reviews, 37, 8, pp. 1838-1859, Neuroscience and Biobehavioral Reviews, 37, 1838-1859
- Publication Year :
- 2013
-
Abstract
- Understanding the cognitive sequela of repeated cocaine use is a growing area of research and is crucial to the development of cognitive models of addiction. We systematically reviewed all available placebo-controlled and case-controlled studies on the acute and long-term effects of cocaine on cognitive functioning. In order to compare the magnitude of cognitive effects across cognitive domains we conducted several meta-analyses on a subset of data from long-term effect studies. Studies on acute cocaine administration suggest enhancement of response inhibition and psychomotor speed, while all other domains appear to be unaffected or not investigated adequately. Long-term effects of cocaine show a wide array of deteriorated cognitive functions, indicating that long term cocaine use is characterized by a general cognitive impairment across functions, rather than by specific cognitive deficits. Literature on long-term cocaine effects is more substantial than literature on acute effects. This comprehensive review outlines possible dissociations and similarities of acute vs. long-term cocaine effects in the human brain. Atherosclerosis after cocaine exposure may underlie cognitive dysfunction, suggesting involvement of multiple brain areas. Acute drug studies are important to the future development of addiction models. (C) 2013 Elsevier Ltd. All rights reserved.
- Subjects :
- Substance abuse
Cognitive
Grondslagen van het publiekrecht
Long-term drug effects
Cognitive Neuroscience
media_common.quotation_subject
Stimulants
Neuroimaging
EVENT-RELATED POTENTIALS
WORKING-MEMORY TASK
DRUG-USE
DCN PAC - Perception action and control
Neuropsychological Tests
DECISION-MAKING
Substance dependency
Behavioral Neuroscience
Cocaine-Related Disorders
Cognition
Cocaine
Event-related potential
Neuropsychology
medicine
Reaction Time
Attention deficit hyperactivity disorder
Humans
Attention
Cognitive skill
Acute drug effects
media_common
Psychomotor learning
Addiction
Brain
DEPENDENT SUBJECTS
medicine.disease
IMPAIRED INHIBITORY CONTROL
ATTENTION-DEFICIT/HYPERACTIVITY-DISORDER
GAMBLING TASK-PERFORMANCE
Neuropsychology and Physiological Psychology
Principles of Public Law
STOP SIGNAL INHIBITION
CEREBRAL-BLOOD-FLOW
Psychology
Cognition Disorders
Clinical psychology
Subjects
Details
- ISSN :
- 01497634
- Database :
- OpenAIRE
- Journal :
- Neuroscience and Biobehavioral Reviews, 37(8), 1838-1859. Elsevier Science, Neuroscience and Biobehavioral Reviews, 37, 8, pp. 1838-1859, Neuroscience and Biobehavioral Reviews, 37, 1838-1859
- Accession number :
- edsair.doi.dedup.....459d53b2bebc652375c2d6ccc780d95d