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BCOR involvement in cancer
- Source :
- Epigenomics
- Publication Year :
- 2019
-
Abstract
- BCOR is a gene that encodes for an epigenetic regulator involved in the specification of cell differentiation and body structure development and takes part in the noncanonical polycomb repressive complex 1. This review provides a comprehensive summary of BCOR’s involvement in oncology, illustrating that various BCOR aberrations, such as the internal tandem duplications of the PCGF Ub-like fold discriminator domain and different gene fusions (mainly BCOR–CCNB3, BCOR–MAML3 and ZC3H7B–BCOR), represent driver elements of various sarcomas such as clear cell sarcoma of the kidney, primitive mesenchymal myxoid tumor of infancy, small round blue cell sarcoma, endometrial stromal sarcoma and histologically heterogeneous CNS neoplasms group with similar genomic methylation patterns known as CNS-HGNET-BCOR. Furthermore, other BCOR alterations (often loss of function mutations) recur in a large variety of mesenchymal, epithelial, neural and hematological tumors, suggesting a central role in cancer evolution.
- Subjects :
- 0301 basic medicine
Cancer Research
Clear-cell sarcoma of the kidney
Cellular differentiation
Review
Cyclin B
Biology
medicine.disease_cause
NO
Central Nervous System Neoplasms
03 medical and health sciences
0302 clinical medicine
oncogenesis
Neoplasms
Proto-Oncogene Proteins
Genetics
medicine
Humans
ESS
Epigenetics
BCOR
Polycomb Repressive Complex 1
PRC1.1
Endometrial stromal sarcoma
epigenetics
CCSK
CNS-HGNET-BCOR
ITD
PRC2
SRBCS
RNA-Binding Proteins
Cancer
Sarcoma
medicine.disease
Repressor Proteins
030104 developmental biology
030220 oncology & carcinogenesis
Mutation
Trans-Activators
Cancer research
biology.protein
Carcinogenesis
epigenetic
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Epigenomics
- Accession number :
- edsair.doi.dedup.....45922e919746199cbe6e4271f6247a57