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Gutsy moves in mice: cellular and molecular dynamics of endoderm morphogenesis
- Source :
- Philosophical Transactions of the Royal Society B: Biological Sciences. 369:20130547
- Publication Year :
- 2014
- Publisher :
- The Royal Society, 2014.
-
Abstract
- Despite the importance of the gut and its accessory organs, our understanding of early endoderm development is still incomplete. Traditionally, endoderm has been difficult to study because of its small size and relative fragility. However, recent advances in live cell imaging technologies have dramatically expanded our understanding of this tissue, adding a new appreciation for the complex molecular and morphogenetic processes that mediate gut formation. Several spatially and molecularly distinct subpopulations have been shown to exist within the endoderm before the onset of gastrulation. Here, we review findings that have uncovered complex cell movements within the endodermal layer, before and during gastrulation, leading to the conclusion that cells from primitive endoderm contribute descendants directly to gut.
- Subjects :
- Endoderm
Morphogenesis
Cell Differentiation
Articles
Histogenesis
Complex cell
Biology
Models, Biological
General Biochemistry, Genetics and Molecular Biology
Cell biology
Gastrointestinal Tract
Gastrulation
Mice
medicine.anatomical_structure
Cell Movement
Live cell imaging
embryonic structures
medicine
Animals
Epithelial–mesenchymal transition
General Agricultural and Biological Sciences
Definitive endoderm
Subjects
Details
- ISSN :
- 14712970 and 09628436
- Volume :
- 369
- Database :
- OpenAIRE
- Journal :
- Philosophical Transactions of the Royal Society B: Biological Sciences
- Accession number :
- edsair.doi.dedup.....457f733426c9545cfa69e1bf16dd0e00