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Metastatic solid tumors to the jaw and oral soft tissue: A retrospective clinical analysis of 44 patients from a single institution
- Source :
- Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery, vol 44, iss 8
- Publication Year :
- 2016
- Publisher :
- Elsevier BV, 2016.
-
Abstract
- PurposeMetastatic solid tumors to the oral cavity are rare, frequently indicative of an end-stage disease process, and associated with poor survival rates. We performed a 20-year retrospective clinical analysis of our institution's cases of solid metastases to the oral cavity, and investigated these patients' clinical outcomes.Material and methodsA retrospective study of patients with metastatic solid tumors to the oral cavity over a 20-year period (October 1996 to September 2015) was conducted at Memorial Sloan Kettering Cancer Center. Patients were selected if they had a histopathologically confirmed diagnosis. Demographic, pathologic, and clinical information were reviewed to identify patient outcomes.ResultsA total of 44 patients with metastatic non-melanocytic non-hematopoietic tumor to the oral cavity were identified: 24 males and 20 females (39 adults and 5 children) with a mean age of 54.3 years. In all, 24 cases involved the jaw and 20 cases involved the oral soft tissue. Eight patients (18.2%) had oral cavity metastases as the first indication of an occult malignancy. In adult patients, the common primary sites were the lungs (n=9, 20%), kidney (n=7, 16%), breast (n=5, 11%), and colon (n=4, 9%); and in pediatric patients the adrenal gland (3/5) was the most common site. Of the adult patients, 33 (84.6%) died of disease. From the time of metastasis diagnosis, patients with jaw metastases had a median and mean survival of 12 months and 27.7 months, respectively. In comparison, patients with oral soft tissue metastases had a median survival time of 5 months, and mean of 8 months. One pediatric patient (20%) died of disease 8 months after metastasis diagnosis.ConclusionMetastatic solid tumors to the oral cavity can be the first sign of a malignancy. Pediatric patients with oral cavity metastases have a better prognosis compared to adult patients. In this series, adults with oral soft tissue involvement had shorter survival times compared to patients with jaw involvement.
- Subjects :
- Male
Gingiva
Mandible
Metastases
Jaw neoplasm
Metastasis
0302 clinical medicine
80 and over
Medicine
Child
Cancer
Aged, 80 and over
Pediatric
Mouth neoplasm
Clinical pathology
Age Factors
Soft tissue
Middle Aged
Prognosis
Jaw Neoplasms
Child, Preschool
030220 oncology & carcinogenesis
Mouth Neoplasms
Female
Oral Surgery
Adult
Pediatric Research Initiative
medicine.medical_specialty
Clinical Sciences
Malignancy
Article
03 medical and health sciences
Clinical Research
Humans
Oral soft tissue
Dental/Oral and Craniofacial Disease
Preschool
Survival analysis
Retrospective Studies
Aged
Metastatic tumor
business.industry
Infant
Retrospective cohort study
030206 dentistry
medicine.disease
Survival Analysis
Surgery
Jaw
Otorhinolaryngology
Dentistry
business
Subjects
Details
- ISSN :
- 10105182
- Volume :
- 44
- Database :
- OpenAIRE
- Journal :
- Journal of Cranio-Maxillofacial Surgery
- Accession number :
- edsair.doi.dedup.....4577d5900fd0ffa6a235cdd68f68e5c3