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Association of the Clinical and Genetic Factors With Superior Vena Cava Arrhythmogenicity in Atrial Fibrillation
- Source :
- Circulation Journal. 82:71-77
- Publication Year :
- 2018
- Publisher :
- Japanese Circulation Society, 2018.
-
Abstract
- BACKGROUND Atrial fibrillation (AF) can be initiated from arrhythmogenic foci within the muscular sleeves that extend not only into the pulmonary veins but also into both vena cavae. The superior vena cava (SVC) is a key target site for catheter ablation. Patients with SVC-derived AF often lack the clinical risk factors of AF.Methods and Results:We conducted a meta-analysis of the clinical and genetic factors of 2,170 AF patients with and without SVC arrhythmogenicity. In agreement with previous reports, the left atrial diameter was smaller in AF patients with SVC arrhythmogenicity. Among 6 variants identified in a previous genome-wide association study in Japanese patients, rs2634073 and rs6584555 were associated with SVC arrhythmogenicity. This finding was confirmed in our meta-analysis using independent cohorts. We also found that SVC arrhythmogenicity was conditionally dependent on age, body mass index, and left ventricular ejection fraction. CONCLUSIONS Both clinical and genetic factors are associated with SVC arrhythmogenicity.
- Subjects :
- Male
0301 basic medicine
medicine.medical_specialty
Vena Cava, Superior
medicine.medical_treatment
Catheter ablation
030204 cardiovascular system & hematology
03 medical and health sciences
0302 clinical medicine
Risk Factors
Superior vena cava
Left atrial
Internal medicine
Atrial Fibrillation
Humans
Medicine
Aged
Ejection fraction
business.industry
Arrhythmias, Cardiac
Atrial fibrillation
General Medicine
Middle Aged
medicine.disease
030104 developmental biology
Target site
cardiovascular system
Cardiology
Female
Cardiology and Cardiovascular Medicine
business
Clinical risk factor
Subjects
Details
- ISSN :
- 13474820 and 13469843
- Volume :
- 82
- Database :
- OpenAIRE
- Journal :
- Circulation Journal
- Accession number :
- edsair.doi.dedup.....456c0ba4d948fd66bb62bf4be24d77e2