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1,7-Annulated indolocarbazoles as cyclin-dependent kinase inhibitors
- Source :
- Bioorganic & Medicinal Chemistry Letters. 14:3217-3220
- Publication Year :
- 2004
- Publisher :
- Elsevier BV, 2004.
-
Abstract
- The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.
- Subjects :
- chemistry.chemical_classification
Indoles
Chemistry
Kinase
Organic Chemistry
Clinical Biochemistry
Carbazoles
Cyclin-Dependent Kinase 4
Pharmaceutical Science
Biological activity
Inhibitory postsynaptic potential
Biochemistry
Chemical synthesis
Cyclin-Dependent Kinases
Enzyme
Cell culture
Proto-Oncogene Proteins
Drug Discovery
Molecular Medicine
Cyclin D1
Signal transduction
Protein kinase A
Protein Kinase Inhibitors
Molecular Biology
Subjects
Details
- ISSN :
- 0960894X
- Volume :
- 14
- Database :
- OpenAIRE
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Accession number :
- edsair.doi.dedup.....456ac3a058024210c3686fd7b2326609
- Full Text :
- https://doi.org/10.1016/j.bmcl.2004.03.105