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Three-Dimensional Printed Design of Antibiotic-Releasing Esophageal Patches for Antimicrobial Activity Prevention
- Source :
- Tissue Engineering Part A. 27:1490-1502
- Publication Year :
- 2021
- Publisher :
- Mary Ann Liebert Inc, 2021.
-
Abstract
- Pharyngoesophageal defects can cause exposure to various bacterial flora and severe inflammation. We fabricated a biodegradable polycaprolactone (PCL) patch composed of both thin film and three-dimensional (3D) printed lattice, and then investigated the efficacy of pharyngoesophageal reconstruction by using 3D printed antibiotic-releasing PCL patches that inhibited early inflammation by sustained tetracycline (TCN) release from both thin PCL films and printed rods implanted in esophageal partial defects. PCL was 3D printed in lattice form on a presolution casted PCL thin film at ∼100 μm resolution. TCN was loaded onto the PCL-printed patches by 3D printing a mixture of TCN and PCL particles melted at 100°C. TCN exhibited sustained release
- Subjects :
- Flora
genetic structures
medicine.drug_class
Polyesters
0206 medical engineering
Antibiotics
Biomedical Engineering
Bioengineering
macromolecular substances
02 engineering and technology
Biochemistry
Microbiology
Biomaterials
03 medical and health sciences
chemistry.chemical_compound
medicine
Animals
030304 developmental biology
0303 health sciences
Tissue Engineering
Tissue Scaffolds
business.industry
technology, industry, and agriculture
food and beverages
X-Ray Microtomography
Antimicrobial
020601 biomedical engineering
Anti-Bacterial Agents
Rats
Severe inflammation
chemistry
Printing, Three-Dimensional
Polycaprolactone
sense organs
business
Subjects
Details
- ISSN :
- 1937335X and 19373341
- Volume :
- 27
- Database :
- OpenAIRE
- Journal :
- Tissue Engineering Part A
- Accession number :
- edsair.doi.dedup.....456a2ed025a96dea2c3b205d8c1e3146