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Surveillance for CMV infection in orthotopic liver transplant recipients
- Source :
- Transplantation. 53(6)
- Publication Year :
- 1992
-
Abstract
- Infection with cytomegalovirus is a major cause of morbidity and mortality following orthotopic liver transplantation. In order that preventive strategies may be devised, a detailed assessment of risk factors for infection and disease is required. We have prospectively assessed 46 orthotopic liver transplant recipients for CMV excretion from multiple sites in order to determine incidence of, and risk factors for, CMV infection and disease. Risk factors for posttransplant CMV infection were donor CMV seropositivity, an increased volume of peritransplant whole-blood transfusion and an increased dose of extra steroid therapy to treat rejection episodes. These findings implicate, respectively, transfer of virus with donor organ, transfer of virus with blood transfusion, and stimulation of reactivation of latent virus in recipients through augmented immunosuppression. The possible ways of preventing or ameliorating these effects are discussed.
- Subjects :
- Adult
Blood transfusion
medicine.medical_treatment
Biopsy
Congenital cytomegalovirus infection
Cytomegalovirus
Disease
medicine.disease_cause
Virus
Herpesviridae
Betaherpesvirinae
Risk Factors
medicine
Humans
Cells, Cultured
Transplantation
biology
business.industry
Immunosuppression
Middle Aged
medicine.disease
biology.organism_classification
Liver Transplantation
Blood
Immunology
Cytomegalovirus Infections
Virus Activation
Viral disease
business
Subjects
Details
- ISSN :
- 00411337
- Volume :
- 53
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Transplantation
- Accession number :
- edsair.doi.dedup.....455c4efc19c107fb6acc42a3071f291f