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Bioactive metal-containing nanomaterials for ferroptotic cancer therapy
- Source :
- Journal of Materials Chemistry B. 8:10461-10473
- Publication Year :
- 2020
- Publisher :
- Royal Society of Chemistry (RSC), 2020.
-
Abstract
- The clinical performance of the current cancer therapies is still far from satisfactory. The emerging ferroptosis-driven therapy strategies reignite the hope of chemotherapy in tumor treatment due to their incredible tumor suppression. Among ferroptosis-based cancer therapies, metal elements have attracted remarkable attention due to their inherent physicochemical properties in inducing ferroptosis of tumor cells quickly and strongly without complex cellular signal transduction. Although the discovery and applications of ferroptosis for tumor treatment have been discussed in many reviews, the unique advantages of metal-containing nanomaterials interfering ferroptotic cancer therapies (MIFCT) have seldom been mentioned. Here, we outline the latest advances of MIFCT comprehensively. Firstly, the functions of different kinds of metal elements or their ions are introduced to illustrate their advantages in MIFCT. Secondly, the emerging metal-containing nanomaterials that are designed to achieve ferroptosis-driven therapy are overviewed, including their ability to boost the Fenton or Fenton-like reaction for reactive oxygen species generation, act as hydrogen peroxide self-providers, damage the reducing system, and disturb cellular communication. Moreover, metal-containing nanomaterials with external energy conversion features for MIFCT are discussed. Finally, the future expectations and challenges of MIFCT for clinical cancer therapy are spotlighted.
- Subjects :
- Computer science
Biomedical Engineering
Cancer therapy
Clinical performance
Metal Nanoparticles
Tumor therapy
Cancer
Nanotechnology
General Chemistry
General Medicine
medicine.disease
Cellular signal transduction
Catalysis
Cell Line
Nanomaterials
External energy
Neoplasms
Reactive oxygen species generation
medicine
Animals
Ferroptosis
Humans
General Materials Science
Reactive Oxygen Species
Subjects
Details
- ISSN :
- 20507518 and 2050750X
- Volume :
- 8
- Database :
- OpenAIRE
- Journal :
- Journal of Materials Chemistry B
- Accession number :
- edsair.doi.dedup.....455451433084f3fce97ed7699033aa3a