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One-pot–Two-step Cascade Synthesis of Quinazolinotriazolobenzodiazepines
- Publication Year :
- 2012
-
Abstract
- An operationally simple, one-pot, two-step cascade method has been developed to afford quinazolino[1,2,3]triazolo[1,4]benzodiazepines. This unique, atom-economical transformation engages five reactive centers (amide, aniline, carbonyl, azide, and alkyne) and employs environmentally benign iodine as a catalyst. The method proceeds via sequential quinazolinone-forming condensation and intramolecular azide–alkyne 1,3-dipolar cycloaddition reactions. Substrate scope, multicomponent examples, and mechanistic insights are discussed.
- Subjects :
- chemistry.chemical_classification
Azides
Cycloaddition Reaction
Molecular Structure
Organic Chemistry
Alkyne
Triazoles
Biochemistry
Cycloaddition
Article
Catalysis
chemistry.chemical_compound
Benzodiazepines
Aniline
chemistry
Intramolecular force
Amide
Alkynes
Organic chemistry
Molecule
Azide
Physical and Theoretical Chemistry
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.doi.dedup.....455101d2a1a37d486031e90f9a248eb2