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Role of diffusion-weighted imaging in the differential diagnosis of benign and malignant lesions of the chest-mediastinum
- Source :
- La radiologia medica. 116:720-733
- Publication Year :
- 2011
- Publisher :
- Springer Science and Business Media LLC, 2011.
-
Abstract
- We retrospectively evaluated the role of diffusion-weighted imaging (DWI) with fat and background signal suppression in the differential diagnosis of benign and malignant lesions of the chest-mediastinum by calculating the mean apparent diffusion coefficient (ADC) values.Thirty-four patients with lung nodules/mediastinal masses underwent magnetic resonance (MR) imaging of the chest with conventional and DWI sequences. All patients had been previously studied with computed tomography (CT). After magnetic resonance (MR) imaging the patients underwent transthoracic CT-guided biopsy or mediastinoscopy. After the histopathological diagnosis had been obtained, the lesions were retrospectively divided into five groups: adenocarcinomas (n=16), squamous cell carcinomas (n=12), chronic pneumonias (n=2), malignant mediastinal tumours (n=2) and typical carcinoids (n=2). We compared ADC values in the different lesion groups using the Mann-Whitney U test.There were statistically significant differences (p0.05) between ADC values of benign and malignant lesions. Using an ADC value of 1.25×10⁻³ mm²/s as a threshold, we were able to differentiate malignant from benign lesions with 91% diagnostic accuracy, 90% sensitivity, 100% specificity, 100% positive predictive value and 57% negative predictive value.Short-tau inversion-recovery echo-planar imaging (STIR-EPI) sequences applied to the chest-mediastinum provided potentially useful images for the differential diagnosis of benign and malignant lesions.
- Subjects :
- Male
medicine.medical_specialty
Biopsy
Carcinoid Tumor
Adenocarcinoma
Mediastinal Neoplasms
Sensitivity and Specificity
Statistics, Nonparametric
Diagnosis, Differential
Predictive Value of Tests
Carcinoma
Humans
Medicine
Effective diffusion coefficient
Radiology, Nuclear Medicine and imaging
Aged
Retrospective Studies
Neuroradiology
medicine.diagnostic_test
business.industry
Ultrasound
Mediastinum
Pneumonia
General Medicine
Middle Aged
medicine.disease
body regions
Diffusion Magnetic Resonance Imaging
medicine.anatomical_structure
Carcinoma, Squamous Cell
Female
Radiology
Differential diagnosis
Tomography, X-Ray Computed
business
Nuclear medicine
Diffusion MRI
Subjects
Details
- ISSN :
- 18266983 and 00338362
- Volume :
- 116
- Database :
- OpenAIRE
- Journal :
- La radiologia medica
- Accession number :
- edsair.doi.dedup.....4550f743bbefc4b050267e18805fb2dd