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Predictive factors of selective mineralocorticoid receptor antagonist treatment in chronic central serous chorioretinopathy
- Source :
- Scientific Reports, Vol 10, Iss 1, Pp 1-8 (2020), Scientific Reports
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Purpose: To compare the macular morphology of good and poor responders to eplerenone treatment in chronic central serous chorioretinopathy (CSCR) patients. Methods: 30 eyes of 29 patients with chronic CSCR were treated with 50 mg/day oral eplerenone and followed up for one year. The integrity of outer retinal layers at baseline was assessed using optical coherence tomography. Patients who showed complete resolution of subretinal fluid at one year were assigned to the good responder group (Group 1), whilst those who showed moderate or no resolution were classified as poor responders (Group 2). Results: Ellipsoid zone interruption, ELM interruption and hyperreflective foci in outer segment (OS) and outer nuclear layer (ONL) was significantly more frequent in Group 2 than in Group 1 (pConclusion: There is higher chance of the resolution of subretinal fluid after eplerenone treatment in CSCR patients with intact outer retinal layers at baseline. Baseline morphologic evaluation of the outer retinal layers on OCT scans can be useful in predicting the response to mineralocorticoid receptor antagonist therapy in these patients.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
medicine.drug_class
Science
Chronic central serous chorioretinopathy
Article
03 medical and health sciences
chemistry.chemical_compound
Medical research
0302 clinical medicine
Mineralocorticoid receptor
Ophthalmology
medicine
Humans
Outer nuclear layer
Aged
Mineralocorticoid Receptor Antagonists
Multidisciplinary
business.industry
Health care
Antagonist
Retinal
Odds ratio
Middle Aged
Eplerenone
Treatment Outcome
030104 developmental biology
medicine.anatomical_structure
Central Serous Chorioretinopathy
chemistry
Mineralocorticoid
Chronic Disease
030221 ophthalmology & optometry
Medicine
Female
business
Biomarkers
Tomography, Optical Coherence
Follow-Up Studies
Forecasting
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 20452322
- Volume :
- 10
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....453f86be466ed908300643a28c400cad