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Lateral hypothalamic activity indicates hunger and satiety states in humans
- Source :
- Annals of Clinical and Translational Neurology
- Publication Year :
- 2017
- Publisher :
- John Wiley and Sons Inc., 2017.
-
Abstract
- Lateral hypothalamic area (LHA) local field potentials (LFPs) were recorded in a Prader–Willi patient undergoing deep brain stimulation (DBS) for obesity. During hunger, exposure to food‐related cues induced an increase in beta/low‐gamma activity. In contrast, recordings during satiety were marked by prominent alpha rhythms. Based on these findings, we have delivered alpha‐frequency DBS prior to and during food intake. Despite reporting an early sensation of fullness, the patient continued to crave food. This suggests that the pattern of activity in LHA may indicate hunger/satiety states in humans but attest to the complexity of conducting neuromodulation studies in obesity.
- Subjects :
- 0301 basic medicine
Food intake
medicine.medical_specialty
Deep brain stimulation
medicine.medical_treatment
satiety
Local field potential
Prader‐Willi syndrome
Brief Communication
hunger
03 medical and health sciences
0302 clinical medicine
Alpha rhythm
Internal medicine
Sensation
medicine
Obesity
hypothalamus
business.industry
General Neuroscience
digestive, oral, and skin physiology
Neuromodulation (medicine)
Clinical neurology
deep brain stimulation
030104 developmental biology
Endocrinology
Hypothalamus
Neurology (clinical)
business
Brief Communications
030217 neurology & neurosurgery
Subjects
Details
- Language :
- English
- ISSN :
- 23289503
- Volume :
- 4
- Issue :
- 12
- Database :
- OpenAIRE
- Journal :
- Annals of Clinical and Translational Neurology
- Accession number :
- edsair.doi.dedup.....45316d3bc4afea5d8a618c420a6e3c50