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Visualizing human photoreceptor and retinal pigment epithelium cell mosaics in a single volume scan over an extended field of view with adaptive optics optical coherence tomography
- Source :
- Biomedical Optics Express
- Publication Year :
- 2020
- Publisher :
- Optica Publishing Group, 2020.
-
Abstract
- Using adaptive optics optical coherence tomography, human photoreceptors and retinal pigment epithelium (RPE) cells are typically visualized on a small field of view of ∼1° to 2°. In addition, volume averaging is required for visualizing the RPE cell mosaic. To increase the imaging area, we introduce a lens based spectral domain AO-OCT system that shows low aberrations within an extended imaging area of 4°×4° while maintaining a high (theoretical) transverse resolution (at >7 mm pupil diameter) in the order of 2 µm. A new concept for wavefront sensing is introduced that uses light mainly originating from the RPE layer and yields images of the RPE cell mosaic in a single volume acquisition. The capability of the instrument for in vivo imaging is demonstrated by visualizing various cell structures within the posterior retinal layers over an extended field of view.
- Subjects :
- genetic structures
Image processing
01 natural sciences
Article
law.invention
010309 optics
03 medical and health sciences
chemistry.chemical_compound
Optics
Optical coherence tomography
law
0103 physical sciences
medicine
Adaptive optics
030304 developmental biology
Physics
Wavefront
0303 health sciences
Retinal pigment epithelium
medicine.diagnostic_test
business.industry
Retinal
eye diseases
Atomic and Molecular Physics, and Optics
Lens (optics)
medicine.anatomical_structure
chemistry
sense organs
business
Preclinical imaging
Biotechnology
Subjects
Details
- ISSN :
- 21567085
- Volume :
- 11
- Database :
- OpenAIRE
- Journal :
- Biomedical Optics Express
- Accession number :
- edsair.doi.dedup.....4529345643e1c8444aa4b8cfda840dff