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Global Epidemiology and Evolutionary History of Staphylococcus aureus ST45
- Source :
- J Clin Microbiol
- Publication Year :
- 2020
-
Abstract
- Staphylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical impact. It is one of the most prevalent carrier lineages but also frequently causes severe invasive disease, such as bacteremia. Little is known about its evolutionary history. In this study, we used whole-genome sequencing to analyze a large collection of 451 diverse ST45 isolates from 6 continents and 26 countries. De novo-assembled genomes were used to understand genomic plasticity and to perform coalescent analyses. The ST45 population contained two distinct sublineages, which correlated with the isolates’ geographical origins. One sublineage primarily consisted of European/North American isolates, while the second sublineage primarily consisted of African and Australian isolates. Bayesian analysis predicted ST45 originated in northwestern Europe about 500 years ago. Isolation time, host, and clinical symptoms did not correlate with phylogenetic groups. Our phylogenetic analyses suggest multiple acquisitions of the SCCmec element and key virulence factors throughout the evolution of the ST45 lineage.
- Subjects :
- 0301 basic medicine
Microbiology (medical)
Methicillin-Resistant Staphylococcus aureus
Staphylococcus aureus
Epidemiology
Lineage (evolution)
030106 microbiology
Population
Virulence
Biology
Coalescent theory
03 medical and health sciences
Phylogenetics
Humans
education
Phylogeny
Whole genome sequencing
education.field_of_study
Phylogenetic tree
SCCmec
Australia
Bayes Theorem
Staphylococcal Infections
Europe
030104 developmental biology
Evolutionary biology
Subjects
Details
- ISSN :
- 1098660X
- Volume :
- 59
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of clinical microbiology
- Accession number :
- edsair.doi.dedup.....45272d48de7711db298d8ecabc40c216