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Efficient regio- and stereoselective access to novel fluorinated ?-aminocyclohexanecarboxylates
- Source :
- Beilstein Journal of Organic Chemistry, Vol 9, Iss 1, Pp 1164-1169 (2013), Beilstein Journal of Organic Chemistry
- Publication Year :
- 2013
-
Abstract
- A regio- and stereoselective method has been developed for the synthesis of novel fluorinated 2-aminocyclohexanecarboxylic acid derivatives with the fluorine attached to position 4 of the ring. The synthesis starts from either cis- or trans-β-aminocyclohex-4-enecarboxylic acids and involves regio- and stereoselective transformation of the ring C–C double bond through iodooxazine formation and hydroxylation, followed by hydroxy–fluorine or oxo–fluorine exchange.
- Subjects :
- stereoselective reaction
Double bond
Stereochemistry
chemistry.chemical_element
aminohapot
Ring (chemistry)
Full Research Paper
hydroxylation
Hydroxylation
lcsh:QD241-441
chemistry.chemical_compound
lcsh:Organic chemistry
epoxidation
lcsh:Science
ta116
chemistry.chemical_classification
amino acids
Organic Chemistry
fluorination
Amino acid
Chemistry
chemistry
Fluorine
Stereoselectivity
lcsh:Q
Subjects
Details
- Language :
- English
- ISSN :
- 18605397
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- Beilstein Journal of Organic Chemistry
- Accession number :
- edsair.doi.dedup.....452312e3e2a6ef70e76f1d033e18b6f7