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Sclerostin and Vascular Pathophysiology
- Source :
- International Journal of Molecular Sciences, International Journal of Molecular Sciences, Vol 21, Iss 4779, p 4779 (2020)
- Publication Year :
- 2020
-
Abstract
- There is cumulating evidence for a contribution of Wnt signaling pathways in multiple processes involved in atherosclerosis and vascular aging. Wnt signaling plays a role in endothelial dysfunction, in the proliferation and migration of vascular smooth muscle cells (VSMCs) and intimal thickening. Moreover, it interferes with inflammation processes, monocyte adhesion and migration, as well as with foam cell formation and vascular calcification progression. Sclerostin is a negative regulator of the canonical Wnt signaling pathway and, accordingly, the consequence of increased sclerostin availability can be disruption of the Wnt signalling cascade. Sclerostin is becoming a marker for clinical and subclinical vascular diseases and several lines of evidence illustrate its role in the pathophysiology of the vascular system. Sclerostin levels increase with aging and persist higher in some diseases (e.g., diabetes, chronic kidney disease) that are known to precipitate atherosclerosis and enhance cardiovascular risk. Current knowledge on the association between sclerostin and vascular diseases is summarized in this review.
- Subjects :
- 0301 basic medicine
Vascular smooth muscle
030209 endocrinology & metabolism
Inflammation
Review
sclerostin
Catalysis
lcsh:Chemistry
Inorganic Chemistry
calcification
03 medical and health sciences
chemistry.chemical_compound
Wnt
0302 clinical medicine
Medicine
Aging
Atherosclerosis
Calcification
Cardiovascular
Chronic kidney disease
Diabetes mellitus
Sclerostin
Humans
Vascular Diseases
Physical and Theoretical Chemistry
Endothelial dysfunction
Vascular Calcification
lcsh:QH301-705.5
Molecular Biology
Wnt Signaling Pathway
Spectroscopy
Foam cell
Adaptor Proteins, Signal Transducing
business.industry
cardiovascular
Organic Chemistry
aging
Wnt signaling pathway
General Medicine
medicine.disease
Pathophysiology
Computer Science Applications
030104 developmental biology
lcsh:Biology (General)
lcsh:QD1-999
chemistry
diabetes mellitus
Cancer research
medicine.symptom
atherosclerosis
business
Biomarkers
chronic kidney disease
Subjects
Details
- ISSN :
- 14220067
- Volume :
- 21
- Issue :
- 13
- Database :
- OpenAIRE
- Journal :
- International journal of molecular sciences
- Accession number :
- edsair.doi.dedup.....4501d460045b6a77cabf0b8e3704d791