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Gabapentin-induced myoclonus in end-stage renal disease
- Source :
- Epilepsia. 46(1)
- Publication Year :
- 2005
-
Abstract
- Summary: Purpose: We analyzed the occurrence and clinical features of myoclonus in patients with end-stage renal disease (ESRD) who were treated with gabapentin (GBP). Methods: We reviewed the medical records of patients with ESRD who were treated with GBP and hospitalized during an 18-month period and analyzed clinical details such as type of myoclonus, doses of GBP, electroencephalographic (EEG) findings, and relation of symptoms to GBP exposure and dosage. Results: Three of 71 patients had myoclonus with GBP doses ranging from 9 mg/kg to 20 mg/kg and within 4 months of treatment onset. Myoclonus was characterized as multifocal, involving all extremities in the three patients. EEG did not show epileptiform discharges with the myoclonus. Myoclonus resolved in the three individuals within 4‐15 days after GBP was discontinued. Conclusions: GBP increases the risk of myoclonus in ESRD. Myoclonus in these individuals was more disabling than that in patients with normal renal function, and discontinuation of GBP is required to restore normal function. Ke yW ords: Gabapentin—Myoclonus—End-stage renal disease.
- Subjects :
- Adult
Male
Myoclonus
congenital, hereditary, and neonatal diseases and abnormalities
medicine.medical_specialty
Spasm
Gabapentin
Cyclohexanecarboxylic Acids
Pain
Neurological disorder
End stage renal disease
Nephropathy
Central nervous system disease
Epilepsy
mental disorders
medicine
Humans
Paresthesia
Amines
gamma-Aminobutyric Acid
business.industry
Middle Aged
medicine.disease
nervous system diseases
Surgery
Neurology
Anesthesia
Kidney Failure, Chronic
Anticonvulsants
Female
Neurology (clinical)
medicine.symptom
business
Kidney disease
medicine.drug
Subjects
Details
- ISSN :
- 00139580
- Volume :
- 46
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Epilepsia
- Accession number :
- edsair.doi.dedup.....44fed4941d43feac2631805966bd9bad