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Coagulopathies and inflammatory diseases: '…glimpse of a Snark'
- Source :
- Current opinion in immunology. 55
- Publication Year :
- 2018
-
Abstract
- Coagulopathies and inflammatory diseases, ostensibly, have distinct underlying molecular bases. Notwithstanding, both are host defense mechanisms to physical injury. In invertebrates, clotting can function directly in anti-pathogen defense. Molecules of the vertebrate clotting cascade have also been directly linked to the regulation of inflammation. We posit that thrombophilia may provide resistance against pathogens in vertebrates. The selective pressure of improved anti-pathogen defense may have retained mutations associated with a thrombophilic state in the human population and directly contributed to enhanced inflammation. Indeed, in some inflammatory diseases, at least a subset of patients can be identified as hypercoagulable. Therefore, anticoagulants such as warfarin or apixaban may have a therapeutic role in some inflammatory diseases.
- Subjects :
- 0301 basic medicine
Pyridones
Immunology
Population
Inflammation
Thrombophilia
Article
03 medical and health sciences
medicine
Immunology and Allergy
Animals
Humans
education
education.field_of_study
business.industry
Warfarin
Anticoagulants
Clotting cascade
medicine.disease
030104 developmental biology
Pyrazoles
medicine.symptom
business
medicine.drug
Subjects
Details
- ISSN :
- 18790372
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Current opinion in immunology
- Accession number :
- edsair.doi.dedup.....44f87cf28f5c6b4c8cb9e60d65a4d45b