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Influence of a two-year steroid treatment on body composition as measured by dual X-ray absorptiometry in boys with Duchenne muscular dystrophy
- Source :
- Neuromuscular Disorders, Neuromuscular Disorders, Elsevier, 2014, 24, pp.467-73, Neuromuscular Disorders, 2014, 24, pp.467-73
- Publication Year :
- 2014
- Publisher :
- Elsevier BV, 2014.
-
Abstract
- Steroids are nowadays routinely used as a long-term treatment in Duchenne muscular dystrophy (DMD). Their effects on body composition were assessed using dual X-ray absorptiometry. The study followed over 2 years 29 genetically confirmed DMD patients: 21 in the steroid-treated group and 8 in the steroid-naïve group. After 2 years of steroid treatment, the lean tissue mass values increased significantly (p0.0001), the percentage of body fat mass remained practically constant (p=0.94) in comparison with the initial visit. In the steroid-naïve patients, there were no significant increases in the lean tissue mass but deterioration in body composition confirmed by a significant increase in the percentage of body fat mass. Besides, significant negative correlations were found between the percentage of body fat mass and the MFM total score (R=-0.79, n=76, p0.0001). A 2-year steroid treatment improves significantly body composition of boys with DMD through a significant increase in lean tissue mass. We suggest that a thorough check of body composition should be carried out before steroid treatment discontinuation in case of overweight gain.
- Subjects :
- Male
medicine.medical_specialty
Adolescent
[SDV]Life Sciences [q-bio]
Duchenne muscular dystrophy
Motor Activity
Fat mass
Absorptiometry, Photon
Initial visit
Internal medicine
medicine
Humans
Dual x-ray absorptiometry
Child
Genetics (clinical)
business.industry
Lean tissue
medicine.disease
Muscular Dystrophy, Duchenne
Endocrinology
Steroid therapy
Neurology
Child, Preschool
Pediatrics, Perinatology and Child Health
Body Composition
Steroids
Composition (visual arts)
Neurology (clinical)
business
Subjects
Details
- ISSN :
- 09608966
- Volume :
- 24
- Database :
- OpenAIRE
- Journal :
- Neuromuscular Disorders
- Accession number :
- edsair.doi.dedup.....44f5561d4b4fc658ce8fb44063ff5ce0
- Full Text :
- https://doi.org/10.1016/j.nmd.2014.03.002