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Influence of a two-year steroid treatment on body composition as measured by dual X-ray absorptiometry in boys with Duchenne muscular dystrophy

Authors :
I. Poirot
Pierre Braillon
Jean Iwaz
S. Fontaine-Carbonnel
Elisabeth André
Carole Vuillerot
C. Berard
P. Rippert
Biostatistiques santé
Département biostatistiques et modélisation pour la santé et l'environnement [LBBE]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE)
Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL)
Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 (LBBE)
Université de Lyon-Université de Lyon-Institut National de Recherche en Informatique et en Automatique (Inria)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)
Source :
Neuromuscular Disorders, Neuromuscular Disorders, Elsevier, 2014, 24, pp.467-73, Neuromuscular Disorders, 2014, 24, pp.467-73
Publication Year :
2014
Publisher :
Elsevier BV, 2014.

Abstract

Steroids are nowadays routinely used as a long-term treatment in Duchenne muscular dystrophy (DMD). Their effects on body composition were assessed using dual X-ray absorptiometry. The study followed over 2 years 29 genetically confirmed DMD patients: 21 in the steroid-treated group and 8 in the steroid-naïve group. After 2 years of steroid treatment, the lean tissue mass values increased significantly (p0.0001), the percentage of body fat mass remained practically constant (p=0.94) in comparison with the initial visit. In the steroid-naïve patients, there were no significant increases in the lean tissue mass but deterioration in body composition confirmed by a significant increase in the percentage of body fat mass. Besides, significant negative correlations were found between the percentage of body fat mass and the MFM total score (R=-0.79, n=76, p0.0001). A 2-year steroid treatment improves significantly body composition of boys with DMD through a significant increase in lean tissue mass. We suggest that a thorough check of body composition should be carried out before steroid treatment discontinuation in case of overweight gain.

Details

ISSN :
09608966
Volume :
24
Database :
OpenAIRE
Journal :
Neuromuscular Disorders
Accession number :
edsair.doi.dedup.....44f5561d4b4fc658ce8fb44063ff5ce0
Full Text :
https://doi.org/10.1016/j.nmd.2014.03.002