Impacts of Different Renal Function Estimation Formulas on Dosing of DOACs and Clinical Outcomes

Authors :: Tze-Fan Chao
Chih-Hsin Yeh
Shang-Hung Chang
Hsin-Fu Lee
Shih Ann Chen
Yi-Hsin Chan
Gregory Y.H. Lip
Ya-Chi Huang
Yung-Hsin Yeh
Chi-Tai Kuo
Source :: Journal of the American College of Cardiology. 76(15)
Publication Year :: 2020
Abstract: Direct oral anticoagulants (DOACs) are increasingly prescribed for stroke prevention in atrial fibrillation (AF) ([1][1]). Randomized trials adopted the Cockcroft-Gault (CG) formula to calculate the estimated glomerular filtration rate (eGFR) for appropriate DOAC dosage adjustments, whereas the

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