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Local Cancer Treatment With Fluorouracil

Authors :
Robert D. Sullivan
Source :
JAMA: The Journal of the American Medical Association. 210:2094
Publication Year :
1969
Publisher :
American Medical Association (AMA), 1969.

Abstract

To the Editor:— It is my considered belief and experience that the local infiltration of fluorouracil ( 208 :536, 1969) in extensive cancers is rarely, if ever, applicable. We have used this technique in small primary and secondary skin cancers to determine if the tumor is sensitive to the agent in a given patient. 1 We saw no objective tumor regressions in this test series to warrant intratumoral therapy. Certainly, large fungating lesions, in my opinion, would be difficult to inject uniformly and are not suitable for this type of therapy. In their case presentation, the dose of fluorouracil was such that the tumor regression might well be due to a systemic effect of the drug. I think the above letter upon which I am commenting could mislead many physicians into using this drug by local injection and result in undue trauma.

Details

ISSN :
00987484
Volume :
210
Database :
OpenAIRE
Journal :
JAMA: The Journal of the American Medical Association
Accession number :
edsair.doi.dedup.....44f407341b99d221af44b34d802b0ee7
Full Text :
https://doi.org/10.1001/jama.1969.03160370078030