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Cognitive stimulation has potential for brain activation in individuals with Rett syndrome
- Source :
- J INTELL DISABIL RES, r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu, instname, UPCommons. Portal del coneixement obert de la UPC, Universitat Politècnica de Catalunya (UPC)
- Publication Year :
- 2021
- Publisher :
- Wiley, 2021.
-
Abstract
- Background: Knowledge regarding neuropsychological training in Rett syndrome (RS) is scarce. The aim of this study was to assess the outcome and the duration of the effect of cognitive stimulation on topographic EEG data in RS. Method: Twenty female children diagnosed with RS were included in the analysis. Girls with RS conducted a cognitive task using an eye-tracker designed to evaluate access and choice skills. EEG data was acquired during the experimental procedure including two 10-minutes baseline stages before and after the task. Topographical changes of several EEG spectral markers including absolute and relative powers, brain symmetry index and entropy were assessed. Results: Topographic significance probability maps suggested statistical decreases on delta activity and increases on beta rhythm associated with the cognitive task. Entropy increased during and after the task, likely related to more complex brain activity. A significant positive interaction was obtained between brain symmetry index (BSI) and age showing that the improvement of interhemispheric symmetry was higher in younger girls (5-10 years). Conclusions: According to our findings, significant alterations of brain rhythms were observed during and after cognitive stimulation, suggesting that cognitive stimulation may have effects on brain activity beyond the stimulation period. Finally, our promising results also showed an increased brain symmetry that was especially relevant for the younger group. This could suggest an interaction of the eye-tracking cognitive task, however, further studies in this field are needed to assess the relation between brain asymmetries and age. We would like to acknowledge specific funding support from the Spanish Patient Associations Mi Princesa Rett and Rettando al Síndrome de Rett. This project has also received funding from Torrons Vicens and the Ministry of Science and Innovation (MICINN), Spain, under contract PID2020-117751RB-I00. CIBER-BBN is an initiative of the Instituto de Salud Carlos III, Spain. A. Bachiller is a Serra Húnter Fellow. A.García-Cazorla is supported by FIS P118/00111 “Instituto de Salud Carlos III (ISCIII)” and “Fondo Europeo de desarrollo regional (FEDER)”. A. Tost has received the predoctoral scholarship FI-AGAUR from the Generalitat de Catalunya.
- Subjects :
- medicine.medical_specialty
Brain activity and meditation
Rett, Síndrome de
Stimulation
Rett syndrome
Cognitive stimulation
Electroencephalography
Audiology
electroencephalography (EEG)
Cognition
Rhythm
Arts and Humanities (miscellaneous)
Rett Syndrome
medicine
Humans
Beta Rhythm
Electroencephalography (EEG)
Child
Brain Symmetry Index
Eye tracking
Cognitive Behavioral Therapy
medicine.diagnostic_test
business.industry
Rehabilitation
Neuropsychology
Brain
medicine.disease
Psychiatry and Mental health
cognitive stimulation
eye-tracking
Neurology
Child, Preschool
Female
Neurology (clinical)
Electroencefalografia
business
Brain symmetry index
Ciències de la salut [Àrees temàtiques de la UPC]
Subjects
Details
- ISSN :
- 13652788 and 09642633
- Volume :
- 66
- Database :
- OpenAIRE
- Journal :
- Journal of Intellectual Disability Research
- Accession number :
- edsair.doi.dedup.....44e5add5c12e5fbf4bf916551b2333b5