Additional file 1: Table S1. of miR-634 restores drug sensitivity in resistant ovarian cancer cells by targeting the Ras-MAPK pathway

Cisplatin sensitivity of cell lines. Table S2. miRNAs that show a ≥1.5 fold change of expression in cisplatin sensitive and resistant cell lines. Table S3. GO-terms that are enriched for miR-634 targets. Table S4. An overview of KEGG and Biocarta pathways that are enriched for miR-634 targets. Figure S1. miR-634 is the only miRNA showing consistent changes in cisplatin sensitive and resistant cell lines. Figure S2. Platinum levels in A2780 DDP cells transfected with miR-634 or scrambled controls. Figure S3. Immunohistochemical staining of primary ovarian cancer cell cultures. Figure S4. miR-634 enhances cisplatin sensitivity. Figure S5. miR-634 enhances carboplatin sensitivity. Figure S6. Predicted miR-634 targets. Figure S7. Overview of the location of the miR-634 target sites in the 3’UTR of its potential target genes. Figure S8. Effect of miR-634 overexpression on luciferase activity of psiCHECK™-2 reporter constructs containing part of the 3’UTR of miR-634 predicted targets. Figure S9. Effect of miR-634 inhibitors on luciferase activity of psiCHECK™-2 reporter constructs containing part of the 3’UTR of miR-634 predicted targets. Figure S10. Correlation between miR-634 expression and its target gene expression in 23 miR-634 expressing primary ovarian cancer samples (TCGA dataset). Figure S11. Effect of PD0325901 on cell survival and cisplatin sensitivity. Figure S12. Detection of miR-634, RNU43 and RNU48 by RT-PCR. (PDF 1609 kb)