Relevance of FcγRIIIa-158V-F polymorphism to recurrence of adult periodontitis in Japanese patients

SUMMARYThe immunoglobulin receptor FcγRIIIa (CD16) is distributed on natural killer (NK) cells, macrophages, and γδ T cells, and is polymorphic. FcγRIIIa-158V has a higher affinity for both monomeric and immune complexed IgG1, IgG3, and IgG4 than IIIa-158F. We determined FcγRIIIa-158V/F genotypes of Japanese patients with adult periodontitis. A significant over-representation of FcγRIIIa-158F was found in patients with recurrence, compared with patients without recurrence, making FcγRIIIA a candidate gene for recurrence risk of adult periodontitis.