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Abundant DNA 6mA methylation during early embryogenesis of zebrafish and pig
- Source :
- Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016), Nature Communications
- Publication Year :
- 2016
- Publisher :
- Nature Portfolio, 2016.
-
Abstract
- DNA N6-methyldeoxyadenosine (6mA) is a well-known prokaryotic DNA modification that has been shown to exist and play epigenetic roles in eukaryotic DNA. Here we report that 6mA accumulates up to ∼0.1–0.2% of total deoxyadenosine during early embryogenesis of vertebrates, but diminishes to the background level with the progression of the embryo development. During this process a large fraction of 6mAs locate in repetitive regions of the genome.<br />DNA 6mA is a poorly understood epigenetic mark present at a low abundance in eukaryotic genomes. Here the authors observe high levels in zebrafish and pig during early embryogenesis enriched to repetitive regions of the genome and followed by attenuation during development.
- Subjects :
- 0301 basic medicine
Swine
Science
General Physics and Astronomy
Embryonic Development
Eukaryotic DNA replication
Biology
Genome
General Biochemistry, Genetics and Molecular Biology
Article
03 medical and health sciences
chemistry.chemical_compound
Deoxyadenosine
Animals
Epigenetics
Zebrafish
Repetitive Sequences, Nucleic Acid
Genetics
Multidisciplinary
Deoxyadenosines
General Chemistry
Methylation
DNA
DNA Methylation
biology.organism_classification
030104 developmental biology
chemistry
Prokaryotic DNA replication
Subjects
Details
- Language :
- English
- ISSN :
- 20411723
- Volume :
- 7
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Nature Communications
- Accession number :
- edsair.doi.dedup.....44a2e6dc23ed8516bfbbdcd1f907de24