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Micronutrients and ovarian cancer: A case-control study in Italy
- Source :
- Annals of Oncology. 12:1589-1593
- Publication Year :
- 2001
- Publisher :
- Elsevier BV, 2001.
-
Abstract
- Background: The role of selected micronutrients, vitamins and minerals in the aetiology of epithelial ovarian cancer was investigated using data from a case-control study conducted between 1992 and 1999 in five Italian areas. Patients and methods:Cases were 1031 patients with histologically confirmed incident epithelial ovarian cancer. Controls were 2411 subjects admitted for acute, non-neoplastic diseases to major hospitals in the same catchment areas. Dietary habits were elicited using a validated food frequency questionnaire including 78 food groups and recipes. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed by quintiles of intake of nutrients. Results: Inverse associations emerged for vitamin E (OR = 0.6; 95% CI: 0.5-0.8), beta-carotene (OR = 0.8; 95% CI: 0.6-1.0), lutein/zeaxanthin (OR = 0.6; 95% CI: 0.5-0.8 for the highest vs. the lowest quintile of intake), and calcium intake (OR = 0.7; 95% CI: 0.6-1.0). When the combined effect of calcium and vitamin E was considered, the OR reached 0.4 (95% CI: 0.3-0.7) for subjects in the highest compared to those in the lowest intake tertile of both micronutrients. Results were consistent across strata of menopausal status, parity and family history of ovarian or breast cancer. Conclusions: The intake of selected micronutrients, which were positively correlated to a diet rich in vegetables and fruits, was inversely associated with ovarian cancer. RI Parpinel, Maria/B-1605-2012
- Subjects :
- Adult
Vitamin
medicine.medical_specialty
Adolescent
medicine.medical_treatment
Physiology
Xanthophylls
Food group
Eating
chemistry.chemical_compound
Breast cancer
Risk Factors
Zeaxanthins
Surveys and Questionnaires
Internal medicine
Odds Ratio
Humans
Vitamin E
Medicine
Micronutrients
Aged
Ovarian Neoplasms
business.industry
Incidence
Lutein
Case-control study
Cancer
Feeding Behavior
Hematology
Odds ratio
Middle Aged
beta Carotene
Micronutrient
medicine.disease
Endocrinology
Italy
Oncology
chemistry
Case-Control Studies
Calcium
Female
business
Subjects
Details
- ISSN :
- 09237534
- Volume :
- 12
- Database :
- OpenAIRE
- Journal :
- Annals of Oncology
- Accession number :
- edsair.doi.dedup.....447a898e2e0045ee2c431071c153d25d