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Soluble TWEAK level: is it a marker for cardiovascular disease in long-term hemodialysis patients?
- Source :
- Journal of Nephrology. 26:136-143
- Publication Year :
- 2012
- Publisher :
- SAGE Publications, 2012.
-
Abstract
- BACKGROUND Reduced soluble tumor necrosis factor-like weak inducer of apoptosis (sTWEAK) levels follow declining renal function, are strongly associated with endothelial dysfunction and predict cardiovascular events in nondialyzed chronic kidney disease patients. In contrast, elevated levels of sTWEAK predict poor survival in hemodialysis (HD) patients. Recent evidence suggests a role for sTWEAK in the pathophysiology of vascular calcification. The aim of the study was to investigate plausible links between sTWEAK, atherosclerosis, arterial stiffness and vascular calcification in HD patients. METHODS Coronary artery calcification score (CACs) determined by multislice computed tomography, arterial stiffness by pulse wave velocity (PWV) and carotid artery intima-media thickness (CA-IMT) by carotid Doppler ultrasonography were assessed in 131 long-term prevalent HD patients. sTWEAK levels were measured by ELISA (Bender MedSystems, Vienna, Austria). RESULTS Mean serum sTWEAK level was 237.0 ± 147.5 pg/mL (range 78-937). sTWEAK level was inversely correlated with CA-IMT at a borderline significance (r=-0.168, p=0.05). Neither carotid-radial PWV nor carotid-femoral PWV values correlated with sTWEAK. sTWEAK level was higher in patients with severe vascular calcification (CACs ≥400) compared to patients with CACs
- Subjects :
- Male
Pathology
medicine.medical_specialty
medicine.medical_treatment
Renal function
Pulse Wave Analysis
Carotid Intima-Media Thickness
Pathogenesis
Vascular Stiffness
Renal Dialysis
Internal medicine
medicine
Humans
cardiovascular diseases
Renal Insufficiency, Chronic
Endothelial dysfunction
Vascular Calcification
Pulse wave velocity
Aged
Analysis of Variance
business.industry
Cytokine TWEAK
Middle Aged
Atherosclerosis
medicine.disease
Coronary Vessels
Pathophysiology
Radiography
Nephrology
Tumor Necrosis Factors
cardiovascular system
Cardiology
Arterial stiffness
Female
Hemodialysis
business
Biomarkers
Kidney disease
Subjects
Details
- ISSN :
- 11218428
- Volume :
- 26
- Database :
- OpenAIRE
- Journal :
- Journal of Nephrology
- Accession number :
- edsair.doi.dedup.....44765ebc9ce5d8a939272eb5ed39baf3