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Measurement of Plasma and Urinary Adrenomedullin in Patients with IgA Nephropathy
- Source :
- Nephron. 78:389-394
- Publication Year :
- 1998
- Publisher :
- S. Karger AG, 1998.
-
Abstract
- In this study, we measured plasma and urinary adrenomedullin (AM) concentrations in 47 patients with IgA nephropathy. Controls were 39 healthy volunteers. Plasma and urinary AM values were measured by specific radioimmunoassay. The plasma AM concentrations were higher, and the urinary AM levels were lower in patients with IgA nephropathy than in healthy volunteers. Plasma AM concentrations showed a positive correlation with serum creatinine and blood urea nitrogen, whereas urinary AM levels correlated negatively with serum creatinine and blood urea nitrogen. The plasma AM concentrations showed a positive correlation with fractional excretions of sodium and potassium. Renal biopsy specimens of patients without renal failure were scored for activity (percentage of glomeruli demonstrating cellular crescent formation, degree of mesangial proliferation and interstitial infiltration; total score = 9). Urinary AM levels were shown to be lower in the group with a high activity (score 3–9) as compared with the group with a low activity (score 0–2) based on renal biopsy. Thus, urinary levels of AM are affected by the degree of the activity in IgA nephropathy, and AM may participate in the pathophysiology of IgA nephropathy.
- Subjects :
- Adult
medicine.medical_specialty
Urinary system
Radioimmunoassay
Urology
Nerve Tissue Proteins
Urine
Blood Urea Nitrogen
Nephropathy
Adrenomedullin
chemistry.chemical_compound
Internal medicine
Natriuretic Peptide, Brain
medicine
Humans
Blood urea nitrogen
Aged
Creatinine
business.industry
Glomerulonephritis, IGA
Glomerulonephritis
Middle Aged
medicine.disease
Endocrinology
chemistry
Peptides
business
Atrial Natriuretic Factor
hormones, hormone substitutes, and hormone antagonists
Kidney disease
Subjects
Details
- ISSN :
- 22353186 and 16608151
- Volume :
- 78
- Database :
- OpenAIRE
- Journal :
- Nephron
- Accession number :
- edsair.doi.dedup.....4474a7073b02b9e597ee8e4624aec4c7