Soft-Tissue Reconstruction after Composite Vertebrectomy and Chest Wall Resection for Spinal Tumors

Background Oncologic resections involving both the spine and chest wall commonly require immediate soft tissue reconstruction to eliminate dead space and protect spinal instrumentation and vital neurovascular structures. We hypothesized that reconstructions of composite resections involving both the thoracic spine and chest wall would have a higher complication rate than reconstructions for resections limited to the thoracic spine alone. Methods We performed a retrospective analysis of all consecutive patients who underwent a thoracic vertebrectomy and soft tissue reconstruction from 2002 to 2017. Patients were divided into two groups: those whose defect was limited to the thoracic spine (TS) and those who also required chest wall resection (TS+CW). Results One hundred patients were included (TS: n=53 vs TS+CW: n=47). TS+CW patients had larger resections, as indicated by a greater incidences of multi-level vertebrectomies (70.2% vs. 17%; p=0.001) and instrumentation of more than 6 vertebral levels (76.6% vs. 26.4%; p=0.001). TS patients were older (58.2 α 10.4 vs 48.6 α 13.9 years; p 1 comorbidity (96.2% vs. 74.5%; p=0.002), and had a greater incidence of metastatic disease (88.7% versus 38.3%; p=0.001). Univariate and multivariate logistic regression analyses demonstrated that composite resections were not significantly associated with a higher rate of surgical, medical, or overall complications. Multivariate logistic regression analysis of the TS+CW subgroup demonstrated that flap separation of the spinal cord from the intrapleural space was protective against complications (odds ratio [OR]=0.22, 95% CI 0.05-0.81; p=0.03). Conclusions Despite the large defect size in TS+CW patients, there was no increase in complications compared to TS patients. In TS+CW patients, separating the exposed spinal cord from the intrapleural space with well-vascularized soft tissue was protective against complications.