Back to Search
Start Over
Outcomes of COVID-19 Infection in Multiple Sclerosis and Related Conditions: One-Year Pandemic Experience of the Multicenter New York COVID-19 Neuroimmunology Consortium (NYCNIC)
- Source :
- Multiple Sclerosis and Related Disorders
- Publication Year :
- 2021
- Publisher :
- Published by Elsevier B.V., 2021.
-
Abstract
- Objective To determine outcomes of COVID-19 in patients with Multiple Sclerosis (MS) and related conditions, and to determine predictors of these outcomes. Methods This was a multicenter, observational cohort study of patients with MS or related CNS autoimmune disorders who developed confirmed or highly suspected COVID-19 infection from 2/1/2020 to 12/31/2020. Main Outcome and Measure The primary outcome measure was hospitalization status due to COVID-19. Severity of infection was measured using a 4-point ordinal scale: 1. home care; 2. hospitalization without mechanical ventilation; 3. hospitalization and mechanical ventilation, and 4. death. Results Of 474 patients in the study, 63.3% had confirmed COVID-19 infection and 93.9% were diagnosed with an MS phenotype. Mean age was 45±13 (mean±SD) years, 72% were female, and 86% were treated with a DMT at the time of infection. 58 patients (12.2%) were hospitalized. 24 patients (5.1%) were critically ill (requiring ICU care or outcome of death), of which 15 patients (3.2%) died. Higher neurological disability and older age independently predicted hospitalization. 85% (102/120) of patients with known antibody results not treated with anti-CD20 therapies were seropositive while only 39.5% (17/43) of patients treated with anti-CD20 demonstrated seropositivity (p
- Subjects :
- Mechanical ventilation
medicine.medical_specialty
Multiple Sclerosis
Coronavirus disease 2019 (COVID-19)
Anti-CD20 therapy
Critically ill
business.industry
Multiple sclerosis
medicine.medical_treatment
COVID-19
General Medicine
medicine.disease
Article
Neuroimmunology
Blunt
Neurology
Internal medicine
Pandemic
medicine
Neurology (clinical)
business
Antibody
Cohort study
Subjects
Details
- Language :
- English
- ISSN :
- 22110356 and 22110348
- Database :
- OpenAIRE
- Journal :
- Multiple Sclerosis and Related Disorders
- Accession number :
- edsair.doi.dedup.....445f552010b52ff39800b4def67e27f5