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Judicious use of sodium-glucose cotransporter 2 inhibitors in patients with diabetes on coronavirus-19 pandemic
- Source :
- Journal of the Chinese Medical Association
- Publication Year :
- 2020
- Publisher :
- Ovid Technologies (Wolters Kluwer Health), 2020.
-
Abstract
- Sodium glucose cotransporter-2 inhibitors (SGLT2i), a novel antidiabetic drug blocks the reabsorption of glucose in proximal tubules of kidney, are demonstrated to have cardiovascular and renal benefits for people with diabetes. The benefits are associated with the significant increase of intrarenal angiotensin-converting enzyme II (ACE2) expression and blood volume contraction. However, the increased ACE2 may be detrimental to patients infected with the coronavirus infection 2019 (COVID-19), which is found to invade cells via the entry receptor of ACE2. Besides, an SGLT2i-induced natriuretic effect may also increase the risk of acute kidney injury and affect the hemodynamic stability during systemic infection disease. In this article, we explain the mechanisms why the use of SGLT2i in people with diabetes may lead to worse outcomes and suggest clinician to judiciously use it during COVID-19 pandemic.
- Subjects :
- Pneumonia, Viral
Blood volume
Peptidyl-Dipeptidase A
030204 cardiovascular system & hematology
Pharmacology
medicine.disease_cause
Betacoronavirus
03 medical and health sciences
0302 clinical medicine
Diabetes mellitus
Diabetes Mellitus
Humans
Medicine
Pandemics
Sodium-Glucose Transporter 2 Inhibitors
Coronavirus
Kidney
SARS-CoV-2
business.industry
Reabsorption
Acute kidney injury
COVID-19
General Medicine
Mini-Review
medicine.disease
Coronavirus infection 2019 (COVID-19)
medicine.anatomical_structure
030220 oncology & carcinogenesis
Sodium/Glucose Cotransporter 2
Angiotensin-converting enzyme 2
Angiotensin-Converting Enzyme 2
Coronavirus Infections
business
Angiotensin-converting enzyme
hormones, hormone substitutes, and hormone antagonists
Sodium glucose cotransporter-2 inhibitors
Subjects
Details
- ISSN :
- 17264901
- Volume :
- 83
- Database :
- OpenAIRE
- Journal :
- Journal of the Chinese Medical Association
- Accession number :
- edsair.doi.dedup.....4459e27e7c28abd97411bb1877ff2cbc